Abstract |
The beneficial effects of pentoxifylline (PTX), which has an anti-inflammatory and renoprotective effect in diabetic nephropathy, are not completely understood. This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltration of ED-1 positive cells at 4 weeks. Further, in diabetic rats, administration of PTX for 4 weeks inhibited the renal inflammatory reaction, and when administration for 8 weeks, it prevented proteinuria. These findings support the hypothesis that prolonged administration enhances the protective effects of PTX.
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Authors | Kum Hyun Han, Sang Youb Han, Han Seong Kim, Young Sun Kang, Dae Ryong Cha |
Journal | Inflammation
(Inflammation)
Vol. 33
Issue 3
Pg. 137-43
(Jun 2010)
ISSN: 1573-2576 [Electronic] United States |
PMID | 19921414
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- CD68 protein, rat
- Ccl2 protein, rat
- Chemokine CCL2
- RNA, Messenger
- Pentoxifylline
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Antigens, CD
(metabolism)
- Antigens, Differentiation, Myelomonocytic
(metabolism)
- Chemokine CCL2
(genetics, urine)
- Diabetes Mellitus, Experimental
(complications, immunology)
- Diabetic Nephropathies
(drug therapy, immunology, pathology)
- Dose-Response Relationship, Drug
- Kidney
(pathology)
- Macrophages
(immunology, pathology)
- Male
- Organ Size
(drug effects)
- Pentoxifylline
(pharmacology)
- Proteinuria
(drug therapy, immunology, pathology)
- RNA, Messenger
(metabolism)
- Rats
- Rats, Sprague-Dawley
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