Abstract |
A new approach to prepare functional polymeric micelles in a one step reaction using the unique catalytic property of PHA synthase is described. A biopolymer-based nanocarrier with cancer targeting capability was successfully synthesized from genetically engineered PHA synthase fused with RGD peptide.
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Authors | Han-Nah Kim, Jin Lee, Hae-Yeong Kim, Young-Rok Kim |
Journal | Chemical communications (Cambridge, England)
(Chem Commun (Camb))
Issue 46
Pg. 7104-6
(Dec 14 2009)
ISSN: 1364-548X [Electronic] England |
PMID | 19920997
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Carriers
- Micelles
- Oligopeptides
- Polyhydroxyalkanoates
- Polymers
- Proteins
- arginyl-glycyl-aspartic acid
- Acyltransferases
- poly(3-hydroxyalkanoic acid) synthase
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Topics |
- Acyltransferases
(metabolism)
- Drug Carriers
(chemical synthesis)
- Drug Delivery Systems
(methods)
- Micelles
- Oligopeptides
(chemistry)
- Polyhydroxyalkanoates
(chemistry)
- Polymers
(chemical synthesis, chemistry)
- Proteins
(chemistry)
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