HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Enzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-protein block copolymers.

Abstract
A new approach to prepare functional polymeric micelles in a one step reaction using the unique catalytic property of PHA synthase is described. A biopolymer-based nanocarrier with cancer targeting capability was successfully synthesized from genetically engineered PHA synthase fused with RGD peptide.
AuthorsHan-Nah Kim, Jin Lee, Hae-Yeong Kim, Young-Rok Kim
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Issue 46 Pg. 7104-6 (Dec 14 2009) ISSN: 1364-548X [Electronic] England
PMID19920997 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drug Carriers
  • Micelles
  • Oligopeptides
  • Polyhydroxyalkanoates
  • Polymers
  • Proteins
  • arginyl-glycyl-aspartic acid
  • Acyltransferases
  • poly(3-hydroxyalkanoic acid) synthase
Topics
  • Acyltransferases (metabolism)
  • Drug Carriers (chemical synthesis)
  • Drug Delivery Systems (methods)
  • Micelles
  • Oligopeptides (chemistry)
  • Polyhydroxyalkanoates (chemistry)
  • Polymers (chemical synthesis, chemistry)
  • Proteins (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: