HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Efficacy and safety of losartan in treatment of hyperuricemia and posttransplantation erythrocytosis: results of a prospective, open, randomized, case-control study.

AbstractBACKGROUND:
Hyperuricemia and posttransplantation erythrocytosis (PTE) are frequent complications after kidney transplantation and are important risk factors for cardiovascular events. Losartan decreases serum uric acid and hemoglobin (Hb) concentrations and may be a useful agent for treatment of hyperuricemia and PTE.
OBJECTIVE:
To evaluate the influence of losartan on serum creatinine (SCr), serum uric acid, and hemoglobin (Hb) concentrations in patients after kidney transplantation and to evaluate the safety profile of losartan in these patients.
PATIENTS AND METHODS:
Sixty-six Han Chinese patients (43 men and 23 women; mean [SD] age, 40.45 [11.50] years) were enrolled in the study. All patients had undergone a first cadaveric donor kidney transplantation at least 3 months previously and had stable graft function with SCr concentration less than 176.8 micromol/L and Hb concentration greater than 110 g/L. The patients were divided into 2 groups (losartan group, n = 34; and control group, n = 32) according to the odevity of patient identification number. Patients in the losartan group received losartan, 50 mg/d; patients in the control group did not receive losartan. Each patient was followed up for 6 months.
RESULTS:
Nine patients in the losartan group and 5 patients in the control group dropped out because of acute renal insufficiency, anemia, acute rejection, or poor compliance. The serum uric acid concentration in the losartan group continuously decreased at months 1, 2, 3, and 6 (P = .12, P = .01, P = .04, and P = .005 compared with baseline, and P = .02, P = .003, P = .02, and P = .006 compared with control), especially in the patients with hyperuricemia (P = .02, P < .001, P = .003, and P < .001 compared with baseline, and P = .02, P = .002, P = .02, and P = .002 compared with control). The Hb level in the losartan group decreased significantly at months 1, 2, 3, and 6 (P = .003, P < .001, P = .004, and P = 0.02 compared with baseline, and P = .001, P < .001, P = .001, and P = .005 compared with control), especially in patients with PTE. In patients without PTE, there was no significant decline in Hb concentration in the losartan group compared with baseline. There was no significant decline in estimated glomerular filtration rate in the losartan group.
CONCLUSIONS:
Losartan may be an effective agent for treatment of hyperuricemia and PTE in Han Chinese patients after kidney transplantation. However, in some patients, losartan may not be safe.
AuthorsX Zhu, J Chen, F Han, M Cheng, L Xu, L Zhang, X Ding, Y Le
JournalTransplantation proceedings (Transplant Proc) Vol. 41 Issue 9 Pg. 3736-42 (Nov 2009) ISSN: 1873-2623 [Electronic] United States
PMID19917377 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Angiotensin II Type 1 Receptor Blockers
  • Immunosuppressive Agents
  • Receptor, Angiotensin, Type 1
  • Angiotensin II
  • Uric Acid
  • Cyclosporine
  • Losartan
Topics
  • Adult
  • Angiotensin II (antagonists & inhibitors)
  • Angiotensin II Type 1 Receptor Blockers
  • Blood Pressure
  • Case-Control Studies
  • Cyclosporine (blood)
  • Female
  • Humans
  • Hyperuricemia (drug therapy, etiology, physiopathology)
  • Immunosuppressive Agents (therapeutic use)
  • Kidney Transplantation (adverse effects, immunology)
  • Losartan (therapeutic use)
  • Male
  • Middle Aged
  • Polycythemia (drug therapy, etiology)
  • Prospective Studies
  • Receptor, Angiotensin, Type 1 (agonists)
  • Safety
  • Uric Acid (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: