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Role of ADP-ribosyl cyclase in the pathogenesis of neurological disorders after coronary artery bypass surgery and experimental ischemia.

Abstract
The pathogenesis of neuronal dysfunction was evaluated from the viewpoint of cellular disturbances in NAD(+) metabolism and changes in activity of NAD(+)-utilizing enzymes (e.g., ADP-ribosyl cyclase/CD38). S-100B concentration and CD38 expression on peripheral blood lymphocytes were altered in patients after surgery for coronary heart disease with extracorporeal circulation. These changes in patients during the early postoperative period correlated with variations in CD38 expression on neuronal cells from postischemic rats with cognitive dysfunction.
AuthorsV V Moroz, A B Salmina, A A Fursov, S V Mikhutkina, K Y Linev, N S Mantorova, S V Shakhmaeva
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 147 Issue 5 Pg. 570-2 (May 2009) ISSN: 1573-8221 [Electronic] United States
PMID19907741 (Publication Type: Journal Article)
Chemical References
  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
  • NAD
  • ADP-ribosyl Cyclase
  • ADP-ribosyl Cyclase 1
Topics
  • ADP-ribosyl Cyclase (metabolism, physiology)
  • ADP-ribosyl Cyclase 1 (metabolism)
  • Animals
  • Brain (cytology)
  • Coronary Artery Bypass
  • Humans
  • Immunoassay
  • Ischemia (metabolism, physiopathology)
  • Male
  • NAD (metabolism)
  • Nerve Growth Factors (metabolism)
  • Neurons (enzymology, pathology)
  • Postoperative Period
  • Rats
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins (metabolism)

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