New treatment option for adult-onset limbal xanthogranuloma.

Abstract

PURPOSE:

The purposes of this study are to report a case of adult-onset juvenile xanthogranuloma and suggest a new treatment option.

METHODS:

A 35-year-old man presented with an isolated mass of the limbus. Biopsy revealed a histiocytic tumor with Touton's giant cells staining positive for CD68 and S-100 but negative for CD1a, consistent with JXG. Two intratumoral injections of triamcinolone acetonide 6 weeks apart were performed. The main outcome measure was 6-months follow up clinically and by ultrasound biomicroscopy.

RESULTS:

The lesion regressed, and corneal thickness returned to normal 3 months after the first injection. An increase in intraocular pressure required topical treatment. No recurrence was seen throughout follow up.

CONCLUSION:

Limbal juvenile xanthogranuloma can be successfully treated with intralesional triamcinolone acetonide, thus avoiding a lamellar keratectomy approach.

• Authors: Martin Hermel, Andreas Donner, Andreas Remky
• Journal: Cornea (Cornea) Vol. 29 Issue 1 Pg. 113-6 (Jan 2010) ISSN: 1536-4798 [Electronic] United States
• PMID: 19907306 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers
• Glucocorticoids
• Triamcinolone Acetonide

Topics

• Adult
• Biomarkers (metabolism)
• Corneal Diseases (drug therapy, metabolism, pathology)
• Follow-Up Studies
• Glucocorticoids (therapeutic use)
• Humans
• Injections, Intralesional
• Limbus Corneae (pathology)
• Male
• Triamcinolone Acetonide (therapeutic use)
• Xanthogranuloma, Juvenile (drug therapy, metabolism, pathology)