Abstract | BACKGROUND: METHODS: All children presenting with AIH in our institution, from 1990 to 2006, were retrospectively included. RESULTS: The study population included 55 children [38 females, 17 males, median age 8 years (ranging from 0.8 to 15)] with type 1 (74.5%), type 2 (20%) or seronegative (5.5%) AIH. The diagnosis was made in 41 of them at the time of acute hepatitis (75%); the other 14 were diagnosed as chronic liver disease (25%). Treatment consisted of corticosteroids and azathioprine in 45 patients or corticosteroids alone in five patients. Complete remission was obtained within 1 year in 31 (69%) patients. The median initial dose of corticosteroids was 1.6 mg/kg/day, and the dose was progressively reduced to 0.32 mg/kg/day at 1 year, 0.24 mg/kg/day at 3 years, 0.11 mg/kg/day at 5 years and 0.05 mg/kg/day at 10 years. Corticosteroids withdrawal was possible in 0% of patients at 1 year, 75% at 3 years, 78% at 5 years and 90% at 10 years. At the end of follow-up, azathioprine was maintained in 36 patients (80%). Total treatment withdrawal was obtained in four patients. CONCLUSION:
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Authors | Jérôme Dumortier, Carlos Torres Arita, Christine Rivet, Catherine LeGall, Raymonde Bouvier, Nicole Fabien, Olivier Guillaud, Sophie Collardeau-Frachon, Jean-Yves Scoazec, Alain Lachaux |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 21
Issue 12
Pg. 1413-8
(Dec 2009)
ISSN: 1473-5687 [Electronic] England |
PMID | 19907227
(Publication Type: Journal Article)
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Chemical References |
- Glucocorticoids
- Azathioprine
- Prednisone
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Topics |
- Adolescent
- Azathioprine
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Glucocorticoids
(administration & dosage, therapeutic use)
- Hepatitis, Autoimmune
(drug therapy)
- Humans
- Infant
- Male
- Prednisone
(administration & dosage, therapeutic use)
- Remission Induction
- Retrospective Studies
- Treatment Outcome
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