Abstract |
A convenient remote controlled synthesis of a new tryptophan analog, l-5-(2-[(18)F] fluoroethoxy)- tryptophan (5-(18)FEHTP) was described. The radiochemical yield within 65min was about 12-16% without decay correction, the radiochemical purity was over 98%, and 5-(18)FEHTP dissolved in saline was stable over 6h at room temperature. The biodistribution of 5-(18)FEHTP in mice and the high uptake of 5-(18)FEHTP in tumor demonstrated that it is very likely a new PET tracer for tumor imaging.
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Authors | Ruifen Li, Shih-Chen Wu, Shih-Chen Wang, Zhe Fu, Yonghong Dang, Li Huo |
Journal | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
(Appl Radiat Isot)
Vol. 68
Issue 2
Pg. 303-8
(Feb 2010)
ISSN: 1872-9800 [Electronic] England |
PMID | 19906535
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Chemical References |
- 5-(2-fluoroethoxy)tryptophan
- Radiopharmaceuticals
- Tryptophan
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Topics |
- Animals
- Brain Neoplasms
(diagnostic imaging, metabolism)
- Image Enhancement
(methods)
- Inflammation
(diagnostic imaging, metabolism)
- Isotope Labeling
(methods)
- Metabolic Clearance Rate
- Mice
- Organ Specificity
- Positron-Emission Tomography
(methods)
- Radiopharmaceuticals
(chemical synthesis, pharmacokinetics)
- Tissue Distribution
- Tryptophan
(analogs & derivatives, chemistry, pharmacokinetics)
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