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Synthesis and evaluation of l-5-(2-[(18)F]fluoroethoxy)tryptophan as a new PET tracer.

Abstract
A convenient remote controlled synthesis of a new tryptophan analog, l-5-(2-[(18)F] fluoroethoxy)-tryptophan (5-(18)FEHTP) was described. The radiochemical yield within 65min was about 12-16% without decay correction, the radiochemical purity was over 98%, and 5-(18)FEHTP dissolved in saline was stable over 6h at room temperature. The biodistribution of 5-(18)FEHTP in mice and the high uptake of 5-(18)FEHTP in tumor demonstrated that it is very likely a new PET tracer for tumor imaging.
AuthorsRuifen Li, Shih-Chen Wu, Shih-Chen Wang, Zhe Fu, Yonghong Dang, Li Huo
JournalApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 68 Issue 2 Pg. 303-8 (Feb 2010) ISSN: 1872-9800 [Electronic] England
PMID19906535 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright (c) 2009 Elsevier Ltd. All rights reserved.
Chemical References
  • 5-(2-fluoroethoxy)tryptophan
  • Radiopharmaceuticals
  • Tryptophan
Topics
  • Animals
  • Brain Neoplasms (diagnostic imaging, metabolism)
  • Image Enhancement (methods)
  • Inflammation (diagnostic imaging, metabolism)
  • Isotope Labeling (methods)
  • Metabolic Clearance Rate
  • Mice
  • Organ Specificity
  • Positron-Emission Tomography (methods)
  • Radiopharmaceuticals (chemical synthesis, pharmacokinetics)
  • Tissue Distribution
  • Tryptophan (analogs & derivatives, chemistry, pharmacokinetics)

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