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The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis.

Abstract
Expression of Id-1 (inhibitors of DNA binding/differentiation protein 1) and TSP-1 (thrombospondin-1) in mucoepidermoid carcinoma and their relationship to pathological features and prognosis was studied. Moderately and poorly differentiated groups had significantly higher Id-1 positive expression rate (p<0.05) than well differentiated carcinoma. Stages III-IV showed significant increase of Id-1 positive expression rate (p<0.05) compared with stages I and II. Id-1 positive expression was significantly higher in patients with cervical lymph node metastasis or relapse at 5 years (p<0.05). After that, patients with negative Id-1 expression had significantly higher tumor-free survival than patients with positive expression (p<0.05). Correlation between the expression of Id-1 and TSP-1 in mucoepidermoid carcinoma was negative (p<0.05). Poorly differentiated groups show significantly lower TSP-1 positive expression rate than well differentiated groups (p<0.05). No significant differences of TSP-1 positive expression were detected with clinical stage. TSP-1 positive expression was significantly lower in patients with cervical lymph node metastasis or relapse at 5 years (p<0.05). After 5 years, patients with positive TSP-1 expression had significantly higher tumor-free survival than patients with negative TSP-1. Positive Id-1 expression is associated with high malignancy/poor prognosis; positive TSP-1 expression is associated with low malignancy/good prognosis. Protein expression status may help assess tumor malignancy and patient prognosis.
AuthorsS Yang, L-J Guo, X-F Tang, K Tan, R-G Gong, A Li, T Yu, Q-H Gao, M Xuan, Y-M Wen, C-M Wang, X-Y Wang
JournalInternational journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 39 Issue 1 Pg. 29-35 (Jan 2010) ISSN: 1399-0020 [Electronic] Denmark
PMID19906510 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2009 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Biomarkers, Tumor
  • Coloring Agents
  • Inhibitor of Differentiation Protein 1
  • Thrombospondin 1
Topics
  • Adult
  • Aged
  • Biomarkers, Tumor (analysis)
  • Carcinoma (pathology)
  • Carcinoma, Mucoepidermoid (pathology, secondary)
  • Cell Differentiation
  • Coloring Agents
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Inhibitor of Differentiation Protein 1 (analysis)
  • Lymphatic Metastasis (pathology)
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local (pathology)
  • Neoplasm Staging
  • Parotid Gland (pathology)
  • Prognosis
  • Retrospective Studies
  • Salivary Gland Neoplasms (pathology)
  • Submandibular Gland (pathology)
  • Survival Rate
  • Thrombospondin 1 (analysis)

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