Expression of Id-1 (inhibitors of
DNA binding/differentiation
protein 1) and
TSP-1 (thrombospondin-1) in
mucoepidermoid carcinoma and their relationship to pathological features and prognosis was studied. Moderately and poorly differentiated groups had significantly higher Id-1 positive expression rate (p<0.05) than well differentiated
carcinoma. Stages III-IV showed significant increase of Id-1 positive expression rate (p<0.05) compared with stages I and II. Id-1 positive expression was significantly higher in patients with cervical
lymph node metastasis or relapse at 5 years (p<0.05). After that, patients with negative Id-1 expression had significantly higher
tumor-free survival than patients with positive expression (p<0.05). Correlation between the expression of Id-1 and
TSP-1 in
mucoepidermoid carcinoma was negative (p<0.05). Poorly differentiated groups show significantly lower
TSP-1 positive expression rate than well differentiated groups (p<0.05). No significant differences of
TSP-1 positive expression were detected with clinical stage.
TSP-1 positive expression was significantly lower in patients with cervical
lymph node metastasis or relapse at 5 years (p<0.05). After 5 years, patients with positive
TSP-1 expression had significantly higher
tumor-free survival than patients with negative
TSP-1. Positive Id-1 expression is associated with high
malignancy/poor prognosis; positive
TSP-1 expression is associated with low
malignancy/good prognosis.
Protein expression status may help assess
tumor malignancy and patient prognosis.