A review of long-term prophylaxis in the rare inherited coagulation factor deficiencies.

Abstract

The rare inherited coagulation factor deficiencies (deficiencies of factors I, II, V, VII, XI, XIII, combined FV + FVII deficiency, combined deficiency of the vitamin K dependent factors and von Willebrand disease type 3) have an aggregate prevalence of approximately 1:100,000. They may cause recurrent life or function threatening haemorrhage. In this article we review the available literature on long-term prophylaxis and, where possible, make recommendations on this important area.

• Authors: T Todd, D J Perry
• Journal: Haemophilia : the official journal of the World Federation of Hemophilia (Haemophilia) Vol. 16 Issue 4 Pg. 569-83 (Jul 01 2010) ISSN: 1365-2516 [Electronic] England
• PMID: 19906159 (Publication Type: Journal Article, Review)

Chemical References

• Blood Coagulation Factors
• Fibrinogen

Topics

• Blood Coagulation Disorders (drug therapy)
• Blood Coagulation Factors (administration & dosage, therapeutic use)
• Fibrinogen
• Humans
• Vitamin K Deficiency (drug therapy)