| Abstract | We investigated the effect of locally applied zinc on the healing of partial-thickness skin wounds in the domestic pig using two zinc compounds (zinc oxide and zinc sulfate) in two different vehicles (a gauze compress and a collagen sponge). The rate of re-epithelialization was determined morphometrically 48 and 64 hr after infliction of standardized square wounds (4.8 cm2 and 400-microns deep) with an electrokeratome. Zinc oxide in gauze significantly (P less than 0.05) increased re-epithelialization of the wounds (33% more epithelialized than control wounds after 64 hr) and in collagen sponge (76% more epithelialized than control wounds after 64 hr). Zinc sulfate had no such stimulatory effect at any dosage or vehicle used. Our results show that topical zinc oxide enhances re-epithelialization of partial-thickness wounds in nutritionally balanced pigs and that the mode of delivery of zinc is probably critical for achieving the beneficial healing effect of zinc. |
| Authors | M S Agren, M Chvapil, L Franzén
(Affiliation: Department of Pathology, Faculty of Health Sciences, Linköping, Sweden.)
|
| Journal | The Journal of surgical research
(J Surg Res)
Vol. 50
Issue 2
Pg. 101-5
(Feb 1991)
ISSN: 0022-4804 UNITED STATES |
| PMID | 1990212
(Publication Type: Journal Article)
|
| Chemical References |
- Sulfates
- Zinc
- Zinc Sulfate
- Povidone
|
| Topics |
- Animals
- Bandages
- Epithelial Cells
- Epithelium
(drug effects)
- Female
- Povidone
(pharmacology)
- Skin
(drug effects, pathology)
- Sulfates
(pharmacology)
- Swine
- Wound Healing
(drug effects)
- Wounds and Injuries
(pathology)
- Zinc
(pharmacology)
- Zinc Sulfate
|
