Abstract | BACKGROUND: A Cochrane review in 2006 concluded that further knowledge is required before recommendation can be made with regard to progesterone in the prevention of preterm birth. OBJECTIVE: SEARCH STRATEGY: A search in the PubMed, Embase, and Cochrane database was performed using the keywords: pregnancy, progesterone, preterm birth/preterm delivery, preterm labor, controlled trial, and randomized controlled trial. SELECTION CRITERIA: Studies on singleton pregnancies. DATA COLLECTION AND ANALYSIS: A meta-analysis was performed on randomized trials including singleton pregnancies with previous preterm birth. MAIN RESULTS: Two new randomized controlled trials of women with previous preterm birth were added to the four analyzed in the Cochrane review, and the meta-analysis of all six studies now showed that progesterone supplementation was associated with a significant reduction of delivery before 32 weeks and of perinatal mortality. Furthermore, a third trial showed a positive effect on women with a short cervix at 23 weeks, and a fourth study showed that progesterone reduces the risk of preterm delivery in women with preterm labor. CONCLUSIONS:
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Authors | Line Rode, Jens Langhoff-Roos, Charlotte Andersson, Jakob Dinesen, Mette Schou Hammerum, Hanne Mohapeloa, Ann Tabor |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 88
Issue 11
Pg. 1180-9
( 2009)
ISSN: 1600-0412 [Electronic] United States |
PMID | 19900136
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
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Topics |
- Female
- Humans
- Infant, Newborn
- Infant, Premature
- Pregnancy
- Premature Birth
(prevention & control)
- Progesterone
(administration & dosage)
- Progestins
(administration & dosage)
- Randomized Controlled Trials as Topic
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