Abstract | PURPOSE: METHODS: A total of 207 individuals with acute and chronic PACG and 205 ethnically matched controls were recruited in the current study. A tag-single nucleotide polymorphism approach was used to investigate this gene. Alleles were determined by PCR restriction fragment length polymorphism. RESULTS: The results show a nominal association between rs1157699 and acute PACG (uncorrected p=0.024 and 0.028 for alleles and genotypes, respectively). Haplotype T(rs840617)C(rs6759535)T(rs1157699) frequency is significantly higher in acute PACG patients than in controls (corrected p=0.012), whereas haplotype T(rs840617)C(rs6759535)C(rs1157699) frequency is significantly lower in acute PACG patients compared with controls (corrected p=0.02). However, no significant difference was detected between chronic PACG and CALCRL tag single nucleotide polymorphisms. CONCLUSIONS: The study suggests a possible role of CALCRL in the pathogenesis of acute PACG but not chronic PACG. A replication of this study with a larger sample size as well as on different populations will be helpful in confirming this finding.
|
Authors | Dan Cao, Xing Liu, Xiangming Guo, Yanhong Cong, Jingjing Huang, Zhen Mao |
Journal | Molecular vision
(Mol Vis)
Vol. 15
Pg. 2202-8
(Oct 27 2009)
ISSN: 1090-0535 [Electronic] United States |
PMID | 19898635
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- CALCRL protein, human
- Calcitonin Receptor-Like Protein
- Genetic Markers
- Receptors, Calcitonin
|
Topics |
- Aged
- Aged, 80 and over
- Calcitonin Receptor-Like Protein
- Case-Control Studies
- Demography
- Female
- Gene Frequency
(genetics)
- Genetic Markers
- Genetic Predisposition to Disease
- Glaucoma, Angle-Closure
(genetics)
- Haplotypes
(genetics)
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
(genetics)
- Receptors, Calcitonin
(genetics)
|