Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma.

Abstract

PURPOSE:

To determine whether the polymorphisms of calcitonin receptor-like receptor gene (CALCRL) are associated with primary angle closure glaucoma (PACG) in a southern Chinese population.

METHODS:

A total of 207 individuals with acute and chronic PACG and 205 ethnically matched controls were recruited in the current study. A tag-single nucleotide polymorphism approach was used to investigate this gene. Alleles were determined by PCR restriction fragment length polymorphism.

RESULTS:

The results show a nominal association between rs1157699 and acute PACG (uncorrected p=0.024 and 0.028 for alleles and genotypes, respectively). Haplotype T(rs840617)C(rs6759535)T(rs1157699) frequency is significantly higher in acute PACG patients than in controls (corrected p=0.012), whereas haplotype T(rs840617)C(rs6759535)C(rs1157699) frequency is significantly lower in acute PACG patients compared with controls (corrected p=0.02). However, no significant difference was detected between chronic PACG and CALCRL tag single nucleotide polymorphisms.

CONCLUSIONS:

The study suggests a possible role of CALCRL in the pathogenesis of acute PACG but not chronic PACG. A replication of this study with a larger sample size as well as on different populations will be helpful in confirming this finding.

• Authors: Dan Cao, Xing Liu, Xiangming Guo, Yanhong Cong, Jingjing Huang, Zhen Mao
• Journal: Molecular vision (Mol Vis) Vol. 15 Pg. 2202-8 (Oct 27 2009) ISSN: 1090-0535 [Electronic] United States
• PMID: 19898635 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CALCRL protein, human
• Calcitonin Receptor-Like Protein
• Genetic Markers
• Receptors, Calcitonin

Topics

• Aged
• Aged, 80 and over
• Calcitonin Receptor-Like Protein
• Case-Control Studies
• Demography
• Female
• Gene Frequency (genetics)
• Genetic Markers
• Genetic Predisposition to Disease
• Glaucoma, Angle-Closure (genetics)
• Haplotypes (genetics)
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• Receptors, Calcitonin (genetics)