Abstract | PURPOSE: METHODS: Twenty-one patients (22 eyes) who manifested persistent subretinal and/or intraretinal fluid after at least 3 monthly intravitreal injections of ranibizumab or bevacizumab were prescribed topical bromfenac (0.09%) ophthalmic solution twice daily for 2 months. The efficacy of topical bromfenac was evaluated by comparing visual acuity (logarithm of the minimal angle of resolution and Snellen equivalent), masked readings of spectral domain optical coherence tomography center-point retinal thickness, and the height of pigment epithelial detachment (when present) at baseline and at 1 month and 2 months after the initiation of combined treatment. RESULTS: The mean visual acuity logarithm of the minimal angle of resolution (Snellen equivalent) at baseline was 0.55 +/- 0.35 (20/70), and it did not change significantly after 1 month (0.53 +/- 0.35; P = 0.41, paired Student's t-test) or 2 months (0.52 +/- 0.34; P = 0.26) after the initiation of combined treatment. The mean central retinal thickness was 311 microm at baseline, 308 microm (P = 0.73, paired Student's t-test) after 1 month, and 299 microm (P = 0.34) after 2 months. In 20 eyes of 19 patients manifesting a pigment epithelial detachment, the mean pigment epithelial detachment height was 275 microm at baseline, 271 microm (P = 0.33, paired Student's t-test) at 1 month, and 274 microm (P = 0.76) at 2 months. There were no adverse events associated with the extended administration of topical bromfenac. CONCLUSION:
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Authors | Sandrine A Zweifel, Michael Engelbert, Samira Khan, K Bailey Freund |
Journal | Retina (Philadelphia, Pa.)
(Retina)
2009 Nov-Dec
Vol. 29
Issue 10
Pg. 1527-31
ISSN: 1539-2864 [Electronic] United States |
PMID | 19898185
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inhibitors
- Anti-Inflammatory Agents, Non-Steroidal
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Benzophenones
- Bromobenzenes
- Vascular Endothelial Growth Factor A
- Bevacizumab
- bromfenac
- Ranibizumab
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Topics |
- Administration, Topical
- Aged
- Aged, 80 and over
- Angiogenesis Inhibitors
(administration & dosage)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects)
- Antibodies, Monoclonal
(administration & dosage)
- Antibodies, Monoclonal, Humanized
- Benzophenones
(administration & dosage, adverse effects)
- Bevacizumab
- Bromobenzenes
(administration & dosage, adverse effects)
- Choroidal Neovascularization
(drug therapy, physiopathology)
- Drug Therapy, Combination
- Exudates and Transudates
- Female
- Humans
- Injections
- Macular Degeneration
(drug therapy, physiopathology)
- Male
- Middle Aged
- Ranibizumab
- Retinal Detachment
(etiology)
- Retinal Pigment Epithelium
(pathology)
- Retrospective Studies
- Treatment Outcome
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Visual Acuity
(physiology)
- Vitreous Body
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