Abstract | BACKGROUND: There are very few and inconclusive data concerning the renin-angiotensin-aldosterone system activity in adults with systemic right ventricles, compared to classic heart failure patients. Therefore, we prospectively evaluated angiotensin II and aldosterone levels in a series of patients following Mustard or Senning procedures for complete transposition of the great arteries. METHODS: Forty-two patients (31 male and 11 female, mean age 20.8 ± 3.7 years), 18.2 ± 2.8 years following atrial switch procedures, were included in the analysis. All the patients underwent comprehensive echocardiographic examinations. Angiotensin II and aldosterone levels were measured with immunoradiometric assays. RESULTS: The mean angiotensin II level was 11.9 ± 9.4 pg/mL; 15 patients (35.7%) had angiotensin II levels exceeding the upper limit of normal values. There was a negative correlation between angiotensin II levels and treatment with angiotensin enzyme inhibitors (r = -0.33, P = 0.03). The mean aldosterone level was 217.7 ± 160.2 pg/mL; 26 patients (61.9%) had aldosterone levels exceeding the upper limit of normal values. Female patients had significantly higher aldosterone levels than male patients (321 ± 248 vs 180 ± 95 pg/mL, P = 0.01). A negative correlation between angiotensin II levels and fractional area change (r = -0.65, P=0.03), and a positive correlation between aldosterone levels and right ventricular end-diastolic area (r = 0.66, P = 0.03) were observed in female but not in male patients. CONCLUSIONS:
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Authors | Piotr Szymański, Anna Klisiewicz, Barbara Lubiszewska, Magdalena Lipczyńska, Mirosław Kowalski, Jadwiga Janas, Piotr Hoffman |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 147
Issue 3
Pg. 366-70
(Mar 17 2011)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 19896738
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Angiotensin II
- Aldosterone
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Topics |
- Adolescent
- Aldosterone
(blood, metabolism)
- Angiotensin II
(blood, metabolism)
- Biomarkers
(blood)
- Blood Pressure
(physiology)
- Female
- Humans
- Hypertension
(blood, physiopathology)
- Immunoradiometric Assay
(methods)
- Male
- Prospective Studies
- Sex Characteristics
- Transposition of Great Vessels
(blood, physiopathology)
- Ventricular Dysfunction, Right
(blood, physiopathology)
- Young Adult
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