Abstract |
Here we firstly investigated the role of miR-138 in multidrug resistance of leukemia cells. miR-138 was found up-regulated in the vincristine-induced multidrug resistance (MDR) leukemia cell line HL-60/VCR as compared with HL-60 cells. Up-regulation of miR-138 could reverse resistance of both P-glycoprotein-related and P-glycoprotein-non-related drugs on HL-60/VCR cells, and promote adriamycin-induced apoptosis, accompanied by increased accumulation and decreased releasing amount of adriamycin. miR-138 could significantly down-regulate the expression of P-glycoprotein, Bcl-2, and the transcription of the multidrug resistance gene 1. Further study of the biological functions of miR-138 might be helpful for developing possible strategies to treat leukemia.
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Authors | Xiaohong Zhao, Li Yang, Jianguo Hu, Jigang Ruan |
Journal | Leukemia research
(Leuk Res)
Vol. 34
Issue 8
Pg. 1078-82
(Aug 2010)
ISSN: 1873-5835 [Electronic] England |
PMID | 19896708
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Chemical References |
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibiotics, Antineoplastic
- Antineoplastic Agents, Phytogenic
- MIRN138 microRNA, human
- MicroRNAs
- Multidrug Resistance-Associated Proteins
- Vincristine
- Doxorubicin
- Luciferases
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Topics |
- ATP Binding Cassette Transporter, Subfamily B, Member 1
(metabolism)
- Antibiotics, Antineoplastic
(pharmacology)
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Apoptosis
(drug effects)
- Blotting, Northern
- Blotting, Western
- Cell Line, Tumor
- Doxorubicin
(pharmacology)
- Drug Resistance, Multiple
(genetics)
- Drug Resistance, Neoplasm
(genetics)
- Gene Expression Regulation, Leukemic
(genetics)
- Humans
- Leukemia
(drug therapy, genetics, pathology)
- Luciferases
(metabolism)
- MicroRNAs
(physiology)
- Multidrug Resistance-Associated Proteins
(genetics, metabolism)
- Vincristine
(pharmacology)
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