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miR-138 might reverse multidrug resistance of leukemia cells.

Abstract
Here we firstly investigated the role of miR-138 in multidrug resistance of leukemia cells. miR-138 was found up-regulated in the vincristine-induced multidrug resistance (MDR) leukemia cell line HL-60/VCR as compared with HL-60 cells. Up-regulation of miR-138 could reverse resistance of both P-glycoprotein-related and P-glycoprotein-non-related drugs on HL-60/VCR cells, and promote adriamycin-induced apoptosis, accompanied by increased accumulation and decreased releasing amount of adriamycin. miR-138 could significantly down-regulate the expression of P-glycoprotein, Bcl-2, and the transcription of the multidrug resistance gene 1. Further study of the biological functions of miR-138 might be helpful for developing possible strategies to treat leukemia.
AuthorsXiaohong Zhao, Li Yang, Jianguo Hu, Jigang Ruan
JournalLeukemia research (Leuk Res) Vol. 34 Issue 8 Pg. 1078-82 (Aug 2010) ISSN: 1873-5835 [Electronic] England
PMID19896708 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright (c) 2010 Elsevier Ltd. All rights reserved.
Chemical References
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antibiotics, Antineoplastic
  • Antineoplastic Agents, Phytogenic
  • MIRN138 microRNA, human
  • MicroRNAs
  • Multidrug Resistance-Associated Proteins
  • Vincristine
  • Doxorubicin
  • Luciferases
Topics
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 (metabolism)
  • Antibiotics, Antineoplastic (pharmacology)
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Apoptosis (drug effects)
  • Blotting, Northern
  • Blotting, Western
  • Cell Line, Tumor
  • Doxorubicin (pharmacology)
  • Drug Resistance, Multiple (genetics)
  • Drug Resistance, Neoplasm (genetics)
  • Gene Expression Regulation, Leukemic (genetics)
  • Humans
  • Leukemia (drug therapy, genetics, pathology)
  • Luciferases (metabolism)
  • MicroRNAs (physiology)
  • Multidrug Resistance-Associated Proteins (genetics, metabolism)
  • Vincristine (pharmacology)

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