Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity.
Abstract | BACKGROUND: Severe anaphylaxis to honeybee or vespid stings is associated with a variety of risk factors, which are poorly defined. OBJECTIVE: Our aim was to evaluate the association of baseline serum tryptase concentrations and other variables routinely recorded during patient evaluation with the frequency of past severe anaphylaxis after a field sting. METHODS: In this observational multicenter study, we enrolled 962 patients with established bee or vespid venom allergy who had a systemic reaction after a field sting. Data were collected on tryptase concentration, age, sex, culprit insect, cardiovascular medication, and the number of preceding minor systemic reactions before the index field sting. A severe reaction was defined as anaphylactic shock, loss of consciousness, or cardiopulmonary arrest. The index sting was defined as the hitherto first, most severe systemic field- sting reaction. Relative rates were calculated with generalized additive models. RESULTS: CONCLUSION:
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Authors | Franziska Ruëff, Bernhard Przybilla, Maria Beatrice Biló, Ulrich Müller, Fabian Scheipl, Werner Aberer, Joëlle Birnbaum, Anna Bodzenta-Lukaszyk, Floriano Bonifazi, Christoph Bucher, Paolo Campi, Ulf Darsow, Cornelia Egger, Gabrielle Haeberli, Thomas Hawranek, Michael Körner, Iwona Kucharewicz, Helmut Küchenhoff, Roland Lang, Oliviero Quercia, Norbert Reider, Maurizio Severino, Michael Sticherling, Gunter Johannes Sturm, Brunello Wüthrich |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 124
Issue 5
Pg. 1047-54
(Nov 2009)
ISSN: 1097-6825 [Electronic] United States |
PMID | 19895993
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Anaphylaxis
(blood, enzymology, epidemiology)
- Animals
- Bee Venoms
(immunology)
- Cohort Studies
- Female
- Humans
- Hypersensitivity
(immunology)
- Insect Bites and Stings
(immunology)
- Male
- Middle Aged
- Prognosis
- Prospective Studies
- Retrospective Studies
- Tryptases
(blood)
- Wasps
(immunology)
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