Abstract |
Sensorimotor function is important for cognitive development; however, little experimental evidence exists to support this assumption. In this study we tested the hypothesis that altered cAMP response element binding ( CREB) protein induction and activity-regulated cytoskeletal-associated gene ( Arc) expression may underlie the suppression of hippocampal neurogenesis and memory impairment associated with early sensorimotor deprivation. Associated memory was evaluated in sensorimotor deprived (T) and sham operated (C) rats using a contextual fear-conditioning task. Hippocampal dentate gyrus (DG) neurogenesis was assessed by Brdu and NeuN labeling. Hippocampal DG CREB signaling was examined by measuring protein and mRNA levels of CREB and activity-regulated cytoskeletal-associated gene ( Arc). Contextual freezing responses in the 1-day recall test were significantly lower in 25- and 35-day-old group T compared to C rats (P<0.01), indicating that hippocampal-dependent memory impairment was caused by early sensorimotor deprivation. Furthermore, group T rats exhibited significantly decreased CREB and Arc activation in the hippocampal DG at 25 and 35 days compared to in group C rats (P<0.01 for both). These changes may underlie decreased neurogenesis and impaired memory. No significant between groups differences were apparent in 45- and 60-day-old rats. These results suggest that early sensorimotor deprivation may alter CREB signaling, decrease Arc activation, suppress neurogenesis and ultimately impair memory.
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Authors | Fei Li, Yuan-Yuan Zhang, Xin-Ming Jing, Cong-Huai Yan, Xiao-Ming Shen |
Journal | Behavioural brain research
(Behav Brain Res)
Vol. 207
Issue 2
Pg. 458-65
(Mar 05 2010)
ISSN: 1872-7549 [Electronic] Netherlands |
PMID | 19891990
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2009 Elsevier B.V. All rights reserved. |
Chemical References |
- Cyclic AMP Response Element-Binding Protein
- Cytoskeletal Proteins
- Nerve Tissue Proteins
- RNA, Messenger
- activity regulated cytoskeletal-associated protein
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Topics |
- Aging
- Animals
- Conditioning, Classical
(physiology)
- Cyclic AMP Response Element-Binding Protein
(metabolism)
- Cytoskeletal Proteins
(metabolism)
- Dentate Gyrus
(physiopathology)
- Fear
(physiology)
- Freezing Reaction, Cataleptic
(physiology)
- Male
- Memory Disorders
(physiopathology)
- Mental Recall
(physiology)
- Motor Activity
(physiology)
- Nerve Tissue Proteins
(metabolism)
- Neurogenesis
(physiology)
- RNA, Messenger
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Sensory Deprivation
(physiology)
- Signal Transduction
(physiology)
- Space Perception
(physiology)
- Time Factors
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