Neuronal degeneration and microglial activation in the ischemic dentate gyrus of the gerbil.

• Abstract: In the present study, we investigated the time-course changes of neuronal degeneration and microglial activation in the gerbil dentate gyrus after transient cerebral ischemia using Fluoro-Jade B histofluorescence staining and immunohistochemistry for Iba-1. Fluoro-Jade B positive cells were observed from 6 hr and markedly increased 1 day after ischemia/reperfusion. Iba-1-immunoreactive microglia were increased and hypertrophied at early time, and Iba-1 immunoreactivity was highest at 2 days after ischemia/reperfusion. These results may be direct evidence on neuronal degeneration and microglial activation in the gerbil dentate gyrus after ischemia/reperfusion.
• Authors: Joong Bum Moon, Choong Hyun Lee, Chan Woo Park, Jun Hwi Cho, In Koo Hwang, Ki-Yeon Yoo, Jung Hoon Choi, Hyung-Cheul Shin, Moo-Ho Won (Affiliation: Department of Emergency Medicine, College of Medicine, Kangwon National University, Chuncheon 200-702, South Korea.)
• Journal: The Journal of veterinary medical science / the Japanese Society of Veterinary Science (J Vet Med Sci) Vol. 71 Issue 10 Pg. 1381-6 (Oct 2009) ISSN: 0916-7250 [Print] Japan
• PMID: 19887747 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Brain Ischemia (pathology)
• Dentate Gyrus (blood supply, pathology)
• Gerbillinae
• Microglia (physiology)
• Neurons (physiology)
• Reperfusion Injury (pathology)