Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.

Abstract

Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM.

• Authors: Katherine N Maloney, John B Macmillan, Christopher A Kauffman, Paul R Jensen, Antonio G Dipasquale, Arnold L Rheingold, William Fenical
• Journal: Organic letters (Org Lett) Vol. 11 Issue 23 Pg. 5422-4 (Dec 03 2009) ISSN: 1523-7052 [Electronic] United States
• PMID: 19883103 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antineoplastic Agents
• lodopyridone

Topics

• Actinobacteria (chemistry)
• Alkaloids (chemistry, isolation & purification, pharmacology)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Crystallography, X-Ray
• Drug Screening Assays, Antitumor
• HCT116 Cells
• Humans
• Marine Biology
• Methicillin-Resistant Staphylococcus aureus (drug effects)
• Microbial Sensitivity Tests
• Molecular Conformation
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular