[Beta blockers in migraine prophylaxis].

Abstract

Beta blockers (beta-adrenoceptor blockers) are known to be used for the prophylactic treatment of migraine. The improvement of migraine in the patients who recieved propranolol for angina pectoris revealed the effectiveness of propranolol in migraine prophylaxis. Many clinical trials have confirmed that propranolol is effective in the prophylactic treatment of migraine. Other beta-blocking drugs, namely nadolol, metoprolol, atenolol, timolol and bisoprolol, have also been demonstrated to be effective in the prophylaxis of migraine. In contrast, several beta blockers with intrinsic sympathetic activity (ISA), such as alprenolol, oxprenolol, pindolol and acebutolol, have not been demonstrated to be effective in migraine prophylaxis. In this review, we have descrived the pharmacologic background and pharmacokinetics of the beta blockers that demonstrated a prophylactic effect for migraine will be described. We have also reviewed the results of clinical trials of beta-blocking drugs for migraine.

• Authors: Toshihiko Shimizu
• Journal: Brain and nerve = Shinkei kenkyu no shinpo (Brain Nerve) Vol. 61 Issue 10 Pg. 1125-30 (Oct 2009) ISSN: 1881-6096 [Print] Japan
• PMID: 19882938 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Adrenergic beta-Antagonists
• Nadolol
• Propranolol
• Metoprolol

Topics

• Adrenergic beta-Antagonists (administration & dosage, pharmacokinetics, pharmacology)
• Drug Administration Schedule
• Humans
• Metoprolol (administration & dosage, pharmacokinetics, pharmacology)
• Migraine Disorders (prevention & control)
• Nadolol (administration & dosage, pharmacokinetics, pharmacology)
• Premedication
• Propranolol (administration & dosage, pharmacokinetics, pharmacology)