Abstract | PURPOSE: METHODS: In a multicenter, double-blind, randomized, placebo-controlled, add-on trial (N = 810), patients were randomized to intravenous (IV) ondansetron/ dexamethasone alone (control) or in combination with either a single 150-mg oral dose of casopitant or 3-day IV/oral casopitant. Quality of life was assessed as impact of nausea and vomiting on daily life using the Functional Living Index Emesis (FLIE) questionnaire. Patients completed the FLIE questionnaire at baseline prior to receiving chemotherapy and after completion of the first cycle of HEC. RESULTS: Patients in the single oral dose and 3-day IV/oral casopitant groups scored higher mean total FLIE scores (115.7 and 114.0, respectively; p ≤ 0.0332) than patients in the control group (107.5), indicating that casopitant patients experienced less impact from nausea and vomiting on daily life. The overall absolute difference in the proportion of patients reporting CINV with no impact on daily life between the single oral casopitant group and the control group was 13%; the difference between the 3-day IV/oral casopitant group and the control group was 14%. CONCLUSION:
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Authors | Cesare Gridelli, Amin M Haiderali, Mark W Russo, Linda M Blackburn, Konstantinos Lykopoulos |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 18
Issue 11
Pg. 1437-44
(Nov 2010)
ISSN: 1433-7339 [Electronic] Germany |
PMID | 19882176
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiemetics
- Antineoplastic Agents
- Piperazines
- Piperidines
- casopitant
- Ondansetron
- Dexamethasone
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Topics |
- Activities of Daily Living
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Antiemetics
(administration & dosage)
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Dexamethasone
(therapeutic use)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Nausea
(chemically induced, prevention & control)
- Neoplasms
(drug therapy)
- Ondansetron
(therapeutic use)
- Piperazines
(administration & dosage)
- Piperidines
(administration & dosage)
- Quality of Life
- Surveys and Questionnaires
- Vomiting
(chemically induced, prevention & control)
- Young Adult
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