HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Progress of research in osteoarthritis. Metalloproteinases in osteoarthritis].

Abstract
Osteoarthritis (OA) is a degenerative joint disease characterized by destruction of articular cartilage induced by accumulated mechanical stresses to joints. Destruction of the articular cartilage in OA is caused by the combination of (1) increased degradation of ECM (extracellular matrix), (2) decreased production of ECM and (3) chondrocyte death. Members of the MMP (matrix metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene families are considered to play key roles in the degradation of cartilage ECM. On the other hand, members of the membrane-type ADAM gene family may be involved in the initiation and progression of OA by regulation of chondrocyte metabolism through shedding of membrane proteins.
AuthorsAiko Okada, Yasunori Okada
JournalClinical calcium (Clin Calcium) Vol. 19 Issue 11 Pg. 1593-601 (Nov 2009) ISSN: 0917-5857 [Print] Japan
PMID19880991 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Membrane Proteins
  • ADAM Proteins
  • Matrix Metalloproteinases
Topics
  • ADAM Proteins (physiology)
  • Animals
  • Cartilage, Articular (metabolism, pathology)
  • Chondrocytes (metabolism, pathology)
  • Extracellular Matrix (metabolism, pathology)
  • Humans
  • Matrix Metalloproteinases (physiology)
  • Membrane Proteins (metabolism)
  • Multigene Family
  • Osteoarthritis (enzymology, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: