Abstract |
Disseminated disease caused by non-tuberculous, environmental mycobacteria (EM) reflects impaired host immunity. Disseminated disease caused by Mycobacterium scrofulaceum has primarily been reported in patients with AIDS. Moreover, observing M. scrofulaceum as the agent of localized disease in childhood has become increasingly rare. We report the first case of disseminated disease caused by M. scrofulaceum in a child with inherited interferon-gamma receptor 1 (IFN-gammaR1) complete deficiency. As in this case, mycobacterial bone infections in IFN-gammaR1 deficiency can sometimes mimic the clinical picture of chronic recurrent multifocal osteomyelitis.
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Authors | Maria Grazia Marazzi, Ariane Chapgier, Anna-Carla Defilippi, Vito Pistoia, Sara Mangini, Cesarina Savioli, Anna Dell'Acqua, Jacqueline Feinberg, Enrico Tortoli, Jean-Laurent Casanova |
Journal | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
(Int J Infect Dis)
Vol. 14
Issue 2
Pg. e167-70
(Feb 2010)
ISSN: 1878-3511 [Electronic] Canada |
PMID | 19880337
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright 2009. Published by Elsevier Ltd. |
Chemical References |
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Topics |
- Child, Preschool
- Foot
(microbiology, pathology)
- Hand
(microbiology, pathology)
- Humans
- Immunologic Deficiency Syndromes
(complications)
- Leg
(microbiology, pathology)
- Male
- Mycobacterium Infections, Nontuberculous
(microbiology, pathology)
- Mycobacterium scrofulaceum
(isolation & purification)
- Receptors, Interferon
(deficiency)
- Tuberculosis, Osteoarticular
(microbiology, pathology)
- Interferon gamma Receptor
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