Abstract |
Topical corticosteroids are effective for the treatment of seborrheic dermatitis. The duration of treatment with mid- to high-potency formulations is limited by the well-known side effects associated with their long-term use; further, topical corticosteroids treat only the inflammation associated with the disease. This study assessed the antifungal activity of a new corticosteroid-free cream against Malassezia spp, which may be an important pathogenic factor in seborrheic dermatitis. This was a single-center, bilateral, open-label pilot study in 10 healthy volunteers. The nonsteroidal cream was applied twice daily to a designated target area on the chest for 7 days, and the number of colony-forming units of Malassezia spp taken by tape stripping after 7 days was compared with baseline. The percentage reduction from baseline to day 7 in the number of colony-forming units of Malassezia spp was 94% on the treated side versus 49% on the untreated side (P = .03). This pilot study shows the nonsteroidal topical cream has antifungal activities. Further exploration into its potential as a therapeutic alternative for seborrheic dermatitis is warranted.
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Authors | Leon Kircik |
Journal | Clinics in dermatology
(Clin Dermatol)
2009 Nov-Dec
Vol. 27
Issue 6 Suppl
Pg. S44-7
ISSN: 1879-1131 [Electronic] United States |
PMID | 19878780
(Publication Type: Journal Article)
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Chemical References |
- Antifungal Agents
- Dermatologic Agents
- Emollients
- Ointments
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Topics |
- Administration, Topical
- Adult
- Antifungal Agents
(administration & dosage)
- Colony Count, Microbial
- Dermatologic Agents
(administration & dosage)
- Drug Evaluation
- Emollients
(administration & dosage)
- Female
- Humans
- Malassezia
(isolation & purification)
- Male
- Middle Aged
- Ointments
- Pilot Projects
- Skin
(microbiology)
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