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An open-label, single-center pilot study to determine the antifungal activity of a new nonsteroidal cream (Promiseb Topical Cream) after 7 days of use in healthy volunteers.

Abstract
Topical corticosteroids are effective for the treatment of seborrheic dermatitis. The duration of treatment with mid- to high-potency formulations is limited by the well-known side effects associated with their long-term use; further, topical corticosteroids treat only the inflammation associated with the disease. This study assessed the antifungal activity of a new corticosteroid-free cream against Malassezia spp, which may be an important pathogenic factor in seborrheic dermatitis. This was a single-center, bilateral, open-label pilot study in 10 healthy volunteers. The nonsteroidal cream was applied twice daily to a designated target area on the chest for 7 days, and the number of colony-forming units of Malassezia spp taken by tape stripping after 7 days was compared with baseline. The percentage reduction from baseline to day 7 in the number of colony-forming units of Malassezia spp was 94% on the treated side versus 49% on the untreated side (P = .03). This pilot study shows the nonsteroidal topical cream has antifungal activities. Further exploration into its potential as a therapeutic alternative for seborrheic dermatitis is warranted.
AuthorsLeon Kircik
JournalClinics in dermatology (Clin Dermatol) 2009 Nov-Dec Vol. 27 Issue 6 Suppl Pg. S44-7 ISSN: 1879-1131 [Electronic] United States
PMID19878780 (Publication Type: Journal Article)
Chemical References
  • Antifungal Agents
  • Dermatologic Agents
  • Emollients
  • Ointments
Topics
  • Administration, Topical
  • Adult
  • Antifungal Agents (administration & dosage)
  • Colony Count, Microbial
  • Dermatologic Agents (administration & dosage)
  • Drug Evaluation
  • Emollients (administration & dosage)
  • Female
  • Humans
  • Malassezia (isolation & purification)
  • Male
  • Middle Aged
  • Ointments
  • Pilot Projects
  • Skin (microbiology)

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