The effect of prostaglandin analogues on central corneal thickness of patients with chronic open-angle glaucoma: a 2-year study on 129 eyes.

Abstract

PURPOSE:

To evaluate the effect of prostaglandin analogues on the central corneal thickness (CCT) of patients with chronic open-angle glaucoma (COAG).

METHODS:

One hundred and twenty-nine eyes were included in this study. Of these, 108 were treated with prostaglandin analogues (latanoprost, travoprost and bimatoprost), while 21 eyes treated with β-blockers were used as controls. CCT was measured before treatment and at 3-month intervals.

RESULTS:

A slight but significant increase in CCT was recorded in the bimatoprost and latanoprost groups. Treatment with bimatoprost produced a constant increase (1.85-8.83 μm) in CCT at all time-points of the study. The CCT rise found in the latanoprost group was significant for the first year. Treatment with travoprost did not affect CCT.

CONCLUSION:

The possibility of corneal thickening under prolonged, local prostaglandin treatment should be investigated further. However, in clinical practice, CCT changes may sometimes influence intraocular pressure measurements significantly.

• Authors: Maria Bafa, Gerasimos Georgopoulos, Constantinos Mihas, Panagiotis Stavrakas, Dimitrios Papaconstantinou, Ioannis Vergados
• Journal: Acta ophthalmologica (Acta Ophthalmol) Vol. 89 Issue 5 Pg. 448-51 (Aug 2011) ISSN: 1755-3768 [Electronic] England
• PMID: 19878123 (Publication Type: Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
• Copyright: © 2009 The Authors. Journal compilation © 2009 Acta Ophthalmol.

Chemical References

• Adrenergic beta-Antagonists
• Amides
• Prostaglandins F, Synthetic
• Prostaglandins, Synthetic
• Cloprostenol
• Latanoprost
• Bimatoprost
• Travoprost

Topics

• Adrenergic beta-Antagonists (administration & dosage)
• Aged
• Amides (administration & dosage, adverse effects)
• Bimatoprost
• Cloprostenol (administration & dosage, adverse effects, analogs & derivatives)
• Cornea (diagnostic imaging, drug effects)
• Female
• Follow-Up Studies
• Glaucoma, Open-Angle (diagnostic imaging, drug therapy)
• Humans
• Intraocular Pressure
• Latanoprost
• Male
• Middle Aged
• Prostaglandins F, Synthetic (administration & dosage, adverse effects)
• Prostaglandins, Synthetic (administration & dosage, adverse effects)
• Travoprost
• Ultrasonography