Abstract | OBJECTIVE: METHODS: Twelve 45-day-old WZS minipigs were randomly divided into three groups (control group, 4% 11S group and 8% 11S group, n = 4), which were respectively orally sensitized (0 - 10d) and orally challenged (16 - 18d, 31d) with diets containing 0%, 4% 11S or 8% 11S soybean proteins to induce anaphylactic reactions. Clinical symptoms, skin prick reactions, serum IgG, serum IgE, histamine, mast cell in the small intestine were observed or measured. RESULTS:
Diarrhea and positive skin prick reactions at different degrees were observed in 11S groups. Compared with the control group, serum IgG, IgE and histamine levels of 4% 11S group at 19d and 32d were significantly higher (P < 0.05), and reached the peak when 11S groups were orally challenged at 19d. The jejunum histamine level was negatively correlated with the mast cell numbers in the jejunum mucosa and sub-mucosa (P < 0.05). Compared with the control, the mast cell number in the jejunum sub-mucosa of 4% 11S group was decreased (P < 0.05). CONCLUSION:
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Authors | Qiong Huang, Haibin Xu, Peng Gao, Haixia Sui, Xiaolian Feng, Yuan Zhi, Haibo Liu |
Journal | Wei sheng yan jiu = Journal of hygiene research
(Wei Sheng Yan Jiu)
Vol. 38
Issue 5
Pg. 531-4
(Sep 2009)
ISSN: 1000-8020 [Print] China |
PMID | 19877507
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Globulins
- Soybean Proteins
- Immunoglobulin E
- glycinin
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Topics |
- Animals
- Food Hypersensitivity
(immunology)
- Globulins
(administration & dosage, adverse effects)
- Immunoglobulin E
(blood)
- Jejunum
(immunology)
- Mast Cells
(immunology)
- Random Allocation
- Soybean Proteins
(administration & dosage, adverse effects)
- Soybeans
(chemistry, genetics)
- Swine
- Swine, Miniature
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