The use of recombinant human BMP-2 as a salvage procedure in the pediatric spine: a report on 3 cases.

Abstract

The study is a retrospective case series. The objective is to review the results after off-label recombinant human BMP-2 (rhBMP-2) use in the pediatric spine after previously failed spinal fusion. Non-union in the pediatric spine is a challenging condition associated with increased morbidity due to instability, neurological impairment or multiple revision surgeries. BMP has been used with good results in the adult spine; however, information on its use in the pediatric population is still lacking. rhBMP-2 was used at our institution at revision posterior spinal surgery in three patients. Solid spinal fusion was achieved in all three cases despite underlying bone dysplasia (Hurler's disease), instability or bony substance loss. No adverse reactions due to rhBMP-2 use were observed. rhBMP-2 should be considered as potential option to achieve spinal fusion in children with compromised bone healing due to congenital, local or systemic conditions.

• Authors: Kiril V Mladenov, Philip Kunkel, Ralf Stuecker
• Journal: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (Eur Spine J) Vol. 19 Suppl 2 Pg. S135-9 (Jul 2010) ISSN: 1432-0932 [Electronic] Germany
• PMID: 19876660 (Publication Type: Case Reports, Journal Article)

Chemical References

• BMP2 protein, human
• Bone Morphogenetic Protein 2
• Recombinant Fusion Proteins

Topics

• Age Factors
• Bone Morphogenetic Protein 2 (pharmacology, therapeutic use)
• Bone Regeneration (drug effects, physiology)
• Child
• Child, Preschool
• Humans
• Male
• Postoperative Complications (drug therapy, etiology, physiopathology)
• Recombinant Fusion Proteins (pharmacology, therapeutic use)
• Retrospective Studies
• Spinal Fusion (adverse effects)
• Spine (growth & development, pathology, surgery)
• Wound Healing (drug effects, physiology)