Abstract | BACKGROUND: MATERIALS AND METHODS: The study population comprised 31 consecutive patients (17 malignant mesotheliomas, nine benign asbestos pleurisies, and five diffuse pleural fibrosis) with a mean age of 61 years between January 2006 and December 2008. Thoracoscopy or image-guided pleural needle biopsy were systematically performed to reveal pathologic diagnosis and/or clinical follow-up for at least 3 years for presence or absence of malignant pleural effusion. ROCs analyses for standardized uptake value (SUV) adjusted to body weight were calculated between benign and malignant pleural diseases. RESULTS:
18F-FDG PET/CT imaging correctly detected the presence of malignancies in 15 of 17 patients with malignant mesothelioma for sensitivity, specificity, and overall accuracy of 88.2%, 92.9%, and 90.3%, respectively. 18F-FDG PET/CT imaging correctly identified 13 of 14 cases of benign pleural disease. The mean SUV values were 6.5 +/- 3.4 for malignant mesothelioma cases and 0.8 +/- 0.6 for benign pleural diseases (p < 0.001). When we compared the two groups of pleural disease, a cut-off value of 2.2 for SUV gave the best accuracy with 94.1%, 100%, 100%, and 93.3% for sensitivity, specificity, positive predictive value, and negative predictive value, respectively. CONCLUSION: Preliminary results of this trial provide evidence that 18F-FDG PET/CT imaging is a highly accurate and reliable noninvasive test to decide for further investigation of differentiating malignant mesothelioma from benign pleural disease.
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Authors | Huseyin Yildirim, Muzaffer Metintas, Emre Entok, Guntulu Ak, Ilknur Ak, Emine Dundar, Sinan Erginel |
Journal | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
(J Thorac Oncol)
Vol. 4
Issue 12
Pg. 1480-4
(Dec 2009)
ISSN: 1556-1380 [Electronic] United States |
PMID | 19875971
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carcinogens
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
- Asbestos
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Asbestos
(adverse effects)
- Carcinogens
(pharmacology)
- Diagnosis, Differential
- Female
- Fluorodeoxyglucose F18
- Humans
- Male
- Mesothelioma
(diagnostic imaging)
- Middle Aged
- Pilot Projects
- Pleural Diseases
(diagnostic imaging, etiology)
- Pleural Neoplasms
(diagnostic imaging)
- Positron-Emission Tomography
(methods)
- Prognosis
- Radiopharmaceuticals
- Tomography, X-Ray Computed
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