Abstract | BACKGROUND: MATERIAL AND METHODS: RESULTS: At univariate analysis, worse DFS was related to features of primary tumor (multifocality P = 0.002; size >2 cm, P = 0.022; grade P = 0.022; absence of estrogen P < 0.001 and progesterone P < 0.001 receptors; HER-2 overexpression P = 0.006; vascular invasion P = 0.039; proliferative fraction > or =20% P = 0.034) and micrometastases (sinusal localization P = 0.010). Among the above-mentioned features, two were strongly associated with worse DFS in the multivariate model, i.e. negative receptorial status [hazard ratio (HR) = 11.24, 95% confidence interval (CI) 4.06-31.09; P < 0.001] and sinusal localization of micrometastasis (HR = 3.66, 1.18-11.36; P = 0.025). The OS was influenced by multifocality (P < 0.001) and receptor status (P = 0.005). CONCLUSION: Our results indicate that in patients affected by breast cancer, in addition to the well-known pathological features of primary tumor, sinusal localization of micrometastasis strongly impacts on the prognosis.
|
Authors | G Masci, L Di Tommaso, I Del Prato, S Orefice, A Rubino, G Gullo, M Zuradelli, R Sacco, M Alloisio, M Eboli, M Incarbone, L Giordano, M Roncalli, A Santoro |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 21
Issue 6
Pg. 1228-1232
(Jun 2010)
ISSN: 1569-8041 [Electronic] England |
PMID | 19875751
(Publication Type: Evaluation Study, Journal Article)
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
(diagnosis, mortality, pathology)
- Carcinoma
(diagnosis, mortality, pathology)
- Female
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Middle Aged
- Prognosis
- Retrospective Studies
- Survival Analysis
- Tissue Distribution
- Tumor Burden
|