Abstract | BACKGROUND: The treatment in non-atopic young children with recurrent wheezing remains controversial. OBJECTIVE: The aim of the study was to compare the response of inhaled budesonide in atopic versus non-atopic infants/preschoolers with recurrent wheezing (more than three episodes in the last year or one episode per month in the last three months). METHODS: One hundred and seventy three infants/preschoolers (mean age 1.58+/-0.9 yrs) with recurrent wheezing without previous use of inhaled corticosteroids were enrolled and divided into two categories: atopics (eosinophils in peripheral blood > or =4%) and non-atopics (<4%). Both groups were treated with budesonide (200 mcg bid delivered by MDI and spacer) for three months. The primary outcome was the prevalence of wheezing exacerbation episodes at the end of the treatment. RESULTS: Thirty-seven out of 173 (21.4%) were atopics and they were significantly younger, more frequently with a father with asthma, maternal grandparents with asthma and rhinitis, paternal and maternal grandparents with eczema, and higher number of wheezing episodes in the last year than non-atopics. At the end of the study, among those with good compliance (>70% of the weekly doses), the proportion of wheezing episodes were similar among atopics and non-atopics (57.7% vs. 44.1%, p=0.25, respectively); the number of exacerbations requiring emergency department (ED) visits and hospital admission were also similar. CONCLUSION:
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Authors | L Campusano, M Pastenes, C Fontecilla, J Escalona, C Salazar, J A Castro-Rodriguez |
Journal | Allergologia et immunopathologia
(Allergol Immunopathol (Madr))
2010 Jan-Feb
Vol. 38
Issue 1
Pg. 31-6
ISSN: 0301-0546 [Print] Singapore |
PMID | 19875223
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Copyright | Copyright 2009 SEICAP. Published by Elsevier Espana. All rights reserved. |
Chemical References |
- Adrenal Cortex Hormones
- Bronchodilator Agents
- Budesonide
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Adult
- Asthma
(complications, drug therapy, prevention & control)
- Bronchodilator Agents
(pharmacology, therapeutic use)
- Budesonide
(pharmacology, therapeutic use)
- Child, Preschool
- Cough
(epidemiology)
- Eosinophilia
(etiology)
- Female
- Follow-Up Studies
- Hospitalization
(statistics & numerical data)
- Humans
- Hypersensitivity, Immediate
(blood, complications, diagnosis, drug therapy)
- Infant
- Male
- Maternal Age
- Prospective Studies
- Recurrence
- Respiratory Sounds
(drug effects)
- Socioeconomic Factors
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