HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Response to budesonide among atopic and non-atopic infants/preschoolers with recurrent wheezing.

AbstractBACKGROUND:
The treatment in non-atopic young children with recurrent wheezing remains controversial.
OBJECTIVE:
The aim of the study was to compare the response of inhaled budesonide in atopic versus non-atopic infants/preschoolers with recurrent wheezing (more than three episodes in the last year or one episode per month in the last three months).
METHODS:
One hundred and seventy three infants/preschoolers (mean age 1.58+/-0.9 yrs) with recurrent wheezing without previous use of inhaled corticosteroids were enrolled and divided into two categories: atopics (eosinophils in peripheral blood > or =4%) and non-atopics (<4%). Both groups were treated with budesonide (200 mcg bid delivered by MDI and spacer) for three months. The primary outcome was the prevalence of wheezing exacerbation episodes at the end of the treatment.
RESULTS:
Thirty-seven out of 173 (21.4%) were atopics and they were significantly younger, more frequently with a father with asthma, maternal grandparents with asthma and rhinitis, paternal and maternal grandparents with eczema, and higher number of wheezing episodes in the last year than non-atopics. At the end of the study, among those with good compliance (>70% of the weekly doses), the proportion of wheezing episodes were similar among atopics and non-atopics (57.7% vs. 44.1%, p=0.25, respectively); the number of exacerbations requiring emergency department (ED) visits and hospital admission were also similar.
CONCLUSION:
Regular budesonide therapy may decrease the episodes of wheezing in infants/preschoolers with recurrent wheezing, independently of atopy.
AuthorsL Campusano, M Pastenes, C Fontecilla, J Escalona, C Salazar, J A Castro-Rodriguez
JournalAllergologia et immunopathologia (Allergol Immunopathol (Madr)) 2010 Jan-Feb Vol. 38 Issue 1 Pg. 31-6 ISSN: 0301-0546 [Print] Singapore
PMID19875223 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
CopyrightCopyright 2009 SEICAP. Published by Elsevier Espana. All rights reserved.
Chemical References
  • Adrenal Cortex Hormones
  • Bronchodilator Agents
  • Budesonide
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Adult
  • Asthma (complications, drug therapy, prevention & control)
  • Bronchodilator Agents (pharmacology, therapeutic use)
  • Budesonide (pharmacology, therapeutic use)
  • Child, Preschool
  • Cough (epidemiology)
  • Eosinophilia (etiology)
  • Female
  • Follow-Up Studies
  • Hospitalization (statistics & numerical data)
  • Humans
  • Hypersensitivity, Immediate (blood, complications, diagnosis, drug therapy)
  • Infant
  • Male
  • Maternal Age
  • Prospective Studies
  • Recurrence
  • Respiratory Sounds (drug effects)
  • Socioeconomic Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: