Abstract |
The biochemical mechanisms of anti-inflammatory effect of endocannabinoid congener N-stearoylethanolamine (NSE) was studied on the model of experimental burn in rats. The animals after the thermal burn of the skin received per os during 7 days the water suspension of NSE in a doze 10 mg/kg of body weight. In the other groups of rats the suspension was applied to the wound (the concentration of NSE was 10 mg/ml). It was shown for the first time that NSE accelerated the process of burn wound healing by the inhibition of proinflammatory cytokines (TNFalpha, IL-6) production. NSE caused the normalization of the iNOS and cNOS activity and of nitrite content in plasma, erythrocytes, liver and spleen of rats. NSE also modified the antioxidant enzymes ( catalase, superoxide dismutase and glutathione peroxidase) activity and diminished the level of lipid peroxidation. The discovered anti-inflammatory NSE properties suggest the possibility of its usage for burn treatment.
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Authors | N M Hula, A A Chumak, A H Berdyshev, O F Mehed', T M Horid'ko, N L Kindruk, H V Kosiakova, O D Zhukov |
Journal | Ukrains'kyi biokhimichnyi zhurnal (1999 )
(Ukr Biokhim Zh (1999))
2009 Mar-Apr
Vol. 81
Issue 2
Pg. 107-16 Ukraine |
PMID | 19873884
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
- Ethanolamines
- Interleukin-6
- N-stearoylethanolamine
- Stearic Acids
- Tumor Necrosis Factor-alpha
- Catalase
- Nitric Oxide Synthase
- Superoxide Dismutase
- Glutathione Reductase
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Topics |
- Administration, Cutaneous
- Administration, Oral
- Animals
- Anti-Inflammatory Agents
(administration & dosage, pharmacology, therapeutic use)
- Antioxidants
(administration & dosage, pharmacology, therapeutic use)
- Burns
(drug therapy, enzymology, immunology, metabolism)
- Catalase
(blood, metabolism)
- Disease Models, Animal
- Erythrocytes
(drug effects, enzymology, metabolism)
- Ethanolamines
(administration & dosage, pharmacology, therapeutic use)
- Glutathione Reductase
(blood, metabolism)
- Interleukin-6
(blood, immunology)
- Liver
(drug effects, enzymology)
- Nitric Oxide Synthase
(metabolism)
- Rats
- Skin
(drug effects, enzymology, injuries, metabolism)
- Spleen
(drug effects, enzymology)
- Stearic Acids
(administration & dosage, pharmacology, therapeutic use)
- Superoxide Dismutase
(blood, metabolism)
- Tumor Necrosis Factor-alpha
(blood, immunology)
- Wound Healing
(drug effects)
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