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PRODUCTION OF A SCURVY-LIKE CONDITION BY FEEDING OF A COMPOUND STRUCTURALLY RELATED TO ASCORBIC ACID.

Abstract
The feeding of glucoascorbic acid, an analog of ascorbic acid, to mice and cotton rats caused the production of a condition exhibiting many of the changes characteristic of scurvy as seen in susceptible species. The condition was not prevented or cured by ascorbic acid, but was cured by removal of the glucoascorbic acid from the ration. The condition was produced in mice fed a highly purified ration. It was not produced in mice fed a natural ration. The presence of a substance in certain plant products which prevented the production of the condition was demonstrated.
AuthorsD W Woolley, L O Krampitz
JournalThe Journal of experimental medicine (J Exp Med) Vol. 78 Issue 5 Pg. 333-9 (Nov 01 1943) ISSN: 0022-1007 [Print] United States
PMID19871333 (Publication Type: Journal Article)

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