Abstract |
1. Neutralizing antibody to equine encephalomyelitis virus was found in the spinal fluid of rabbits sufficiently vaccinated with active or formalin-inactivated virus. Antibody was specific for the Western or for the Eastern virus. 2. Neutralizing capacity of spinal fluid was equivalent to that of a 1/300 dilution of serum of the same animal, and was of the same order of magnitude as that of perfused brain of a vaccinated animal. 3. Vaccinated rabbits which showed antibody in the spinal fluid resisted intracerebral or intracisternal injection of active virus. This immunity was specific, i.e., there was no cross-reaction between the Eastern and Western virus after vaccination with formalin-inactivated virus. On the other hand, lack of antibody in the spinal fluid, even when antibody was demonstrable in the undiluted serum, was associated with lack of cerebral resistance.
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Authors | I M Morgan, R W Schlesinger, P K Olitsky |
Journal | The Journal of experimental medicine
(J Exp Med)
Vol. 76
Issue 4
Pg. 357-69
(Oct 01 1942)
ISSN: 0022-1007 [Print] United States |
PMID | 19871243
(Publication Type: Journal Article)
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