Augmentation of radiation-induced apoptosis by ellagic acid.

Abstract

This study evaluates the potential of ellagic acid (EA) as an enhancer of radiation-induced apoptosis in cancer cells. HeLa cells treated with EA and gamma radiation showed increased superoxide generation, upregulated p53 protein expression, and decreased antioxidant enzymes. We also found that EA and radiation enhance capase-3 activity via oxidative stress, increased intracellular calcium levels, and phospholipase C and cause a drop in mitochondrial potential. These results might provide a basis for prominent reduction of cancer cell using EA as an adjunct to radiotherapy and an opportunity to lower the toxic radiation doses to improve the quality of life.

• Authors: Sushma Madhukar Bhosle, Vidhula R Ahire, Monica S Henry, Vikas S Thakur, Nagraj G Huilgol, Kaushala Prasad Mishra
• Journal: Cancer investigation (Cancer Invest) Vol. 28 Issue 3 Pg. 323-30 (Mar 2010) ISSN: 1532-4192 [Electronic] England
• PMID: 19863348 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Radiation-Sensitizing Agents
• Reactive Oxygen Species
• Tumor Suppressor Protein p53
• Superoxides
• Ellagic Acid
• Glutathione Peroxidase
• Caspase 3

Topics

• Apoptosis (drug effects, radiation effects)
• Caspase 3 (metabolism)
• Ellagic Acid (pharmacology)
• Glutathione Peroxidase (analysis)
• HeLa Cells
• Humans
• Oxidative Stress
• Radiation-Sensitizing Agents (pharmacology)
• Reactive Oxygen Species (metabolism)
• Superoxides (metabolism)
• Tumor Suppressor Protein p53 (analysis)