Abstract |
Several lines of evidence support the role of monoaminergic and cholinergic dysregulation in attention deficit hyperactivity disorder ( ADHD) and the concept that peripheral blood neurotransmission indices may represent valuable surrogate CNS markers. We determined platelet MAO-B activity (p- MAO-B) and lymphocyte muscarinic cholinergic receptor binding (l-MR) in 44 unmedicated ADHD children (aged 9.1 +/- 2.87 years) and in 26 age-matched controls for comparison. Lower levels of p- MAO-B (approximately 35%) and l-MR (approximately 55%) in ADHD were observed compared with controls. Differences were gender-dependent: p- MAO-B was reduced in males only (5.20 +/- 2.99 vs 8.46 +/- 5.1 nmol mg(-1) protein h(-1) in ADHD and controls, respectively) and l-MR in females only ( ADHD vs control: 6.63 +/- 1.75 and 15.30 +/- 8.35 fmol 10(-6) cells). The clinical significance was corroborated by the correlation between these markers and severity of specific symptoms: lower p- MAO-B associated with increased inattention scores (Conners' teacher-rating scale); lower l-MR associated with increased score for oppositional-defiant disorder (ODD) (SNAP-IV); and trend towards correlation between increased inattention (SNAP-IV) and lower l-MR.
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Authors | Teresa Coccini, Alessandro Crevani, Giorgio Rossi, Francesca Assandri, Umberto Balottin, Roberta Di Nardo, Luigi Manzo |
Journal | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
(Biomarkers)
Vol. 14
Issue 7
Pg. 513-22
(Nov 2009)
ISSN: 1366-5804 [Electronic] England |
PMID | 19863190
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Receptor, Muscarinic M1
- Monoamine Oxidase
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Topics |
- Attention Deficit Disorder with Hyperactivity
(blood, psychology)
- Binding, Competitive
- Biomarkers
(blood)
- Blood Platelets
(enzymology)
- Child
- Child, Preschool
- Female
- Humans
- Lymphocytes
(metabolism)
- Male
- Monoamine Oxidase
(blood)
- Psychiatric Status Rating Scales
- Receptor, Muscarinic M1
(blood, metabolism)
- Sex Factors
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