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Differential expression of fibulins in the uterosacral ligaments of women with uterine prolapse.

AbstractPURPOSE:
To compare fibulin-3 (FIB-3) and fibulin-5 (FIB-5) expressions in uterosacral ligaments (USL) of women with and without uterine prolapse.
STUDY DESIGN:
USL were sampled in a standardized fashion from women with (n = 8) or without (n = 8) uterine prolapse. Quantitative Real-Time PCR was performed to measure mRNA and immunohistochemistry to assess protein expression.
RESULTS:
FIB-3 mRNA expression and FIB-3 staining intensity was similar in the USL of women with and without uterine prolapse {[(FIB-3 mean +/- SD mRNA relative units) 0.45 +/- 0.41 vs. 0.46 +/- 0.82, NS] and [Intensity score, median (range), 1(0-1) vs. 1(0-1), NS]}. Both FIB-5 mRNA expression and FIB-5 staining intensity was significantly decreased in USL from women with uterine prolapse compared to women without prolapse {[(FIB-5 mean +/- SD mRNA relative units) 0.07 +/- 0.02 vs. 0.26 +/- 0.20, P = 0.02] and [Intensity score, median (range), 0(0-2) vs. 3(2-3), P = 0.002]}.
CONCLUSION:
FIB-5 expression is decreased in USL of women with uterine prolapse.
AuthorsPeter Takacs, Mehdi Nassiri, Keith Candiotti, Jinfeng Yang, Sujata Yavagal, Carlos A Medina
JournalArchives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 282 Issue 4 Pg. 389-94 (Oct 2010) ISSN: 1432-0711 [Electronic] Germany
PMID19862539 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • EFEMP1 protein, human
  • Extracellular Matrix Proteins
  • FBLN5 protein, human
  • RNA, Messenger
Topics
  • Adult
  • Case-Control Studies
  • Extracellular Matrix Proteins (metabolism)
  • Female
  • Florida
  • Humans
  • Immunohistochemistry
  • Ligaments (metabolism)
  • Middle Aged
  • Polymerase Chain Reaction
  • RNA, Messenger (genetics, metabolism)
  • Sacrum (metabolism)
  • Uterine Prolapse (genetics, metabolism)

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