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Use of sodium thiosulfate in the treatment of calciphylaxis.

Abstract
Calciphylaxis is an infrequent but severe entity found in chronic dialysis patients. Its clinical pattern consists of tissue ischemia with itchy and painful subcutaneous nodules and plaques, most often located on the abdomen, buttocks, thighs and/or legs. These injuries evolve to extensive superficial necrosis of the skin overlying the panniculitis, with ulceration, overinfection and consequent sepsis. Current treatment modalities used to counteract this pathology are not entirely effective. A new treatment reported for calciphylaxis, is the use of intravenous sodium thiosulfate. This inorganic salt is already used in the treatment of intoxication caused by cyanide, in patients with calcific nephrolithiasis and tumoral calcinosis, with very good and safe results. We herewith report a case of calciphylaxis that was cured using intravenous sodium thiosulphate treatment.
AuthorsCarlos G Musso, Paula Enz, Flavia Vidal, Rodolfo Gelman, Aldana Lizarraga, Luis Di Giuseppe, Alicia Kowalczuk, Leonardo Garfi, Ricardo Galimberti, Luis Algranati
JournalSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (Saudi J Kidney Dis Transpl) Vol. 20 Issue 6 Pg. 1065-8 (Nov 2009) ISSN: 1319-2442 [Print] Saudi Arabia
PMID19861872 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Chelating Agents
  • Thiosulfates
  • sodium thiosulfate
Topics
  • Calciphylaxis (drug therapy, pathology)
  • Chelating Agents (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Infusions, Intravenous
  • Kidney Failure, Chronic (therapy)
  • Middle Aged
  • Renal Dialysis
  • Skin (pathology)
  • Thiosulfates (administration & dosage, therapeutic use)
  • Treatment Outcome

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