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Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide.

AuthorsPaul K Fyfe, Vincenzo A Rao, Aleksandra Zemla, Scott Cameron, William N Hunter
JournalAngewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 48 Issue 48 Pg. 9176-9 ( 2009) ISSN: 1521-3773 [Electronic] Germany
PMID19859929 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antitubercular Agents
  • Pyrazinamide
  • Nicotinamidase
Topics
  • Acinetobacter baumannii (enzymology)
  • Antitubercular Agents (chemistry, pharmacology)
  • Catalytic Domain
  • Enzyme Activation (drug effects)
  • Models, Molecular
  • Nicotinamidase (chemistry, metabolism)
  • Protein Structure, Tertiary
  • Pyrazinamide (chemistry, pharmacology)
  • Substrate Specificity

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