Evolution of bone disease at 2 years after transplantation: a single-center study.

Abstract

Posttransplant bone disease is caused by renal osteodystrophy. We sought to examine bone mineral density (BMD) among 90 renal allograft recipients of mean age 42.7 +/- 11.4 years to identify factors preventing bone loss at 2 years posttransplant. Subjects treated with cyclosporine or tacrolimus plus azathioprine/MMF and prednisone underwent BMD estimates of the lumbar spine (LS) and of the proximal femur using dual energy x-ray absorptiometry (DEXA) at 3 months and every 6 months for 2 years. We assayed markers of bone remodeling: intact parathyroid hormone (iPTH), calcitriol, osteocalcin, and carboxyterminal telopeptide of type I collagen on day 3, as well as month 1 and every 6 months after transplantation. At the initial measurement, we observed osteopenia (OSP) among 35% in the LS and 52% in the femur: there was osteoporosis in 8.3%. The prevalence of OSP increased during the first year, thereafter decreasing to the initial value, but the rate of osteoporosis did not change significantly (8.3% vs 6.0%). BMD and Z-score decreased during the first and increased in the second year; 27% of patients regained initial values and 38% higher ones. BMD gains in the LS and femur were observed among subjects with higher calcitriol levels during the first 6 months (P < .01), higher osteocalcin (P < .05), higher estimated glomerular filtration rate during 1-24 months and in the tacrolimus group. Improvement of LS BMD occurred in younger patients (38 vs 46 years; P < .027); BMD gain in the femur correlated with higher levels of iPTH from 1-12 months (P < .01). The tacrolimus group showed higher Z-scores in the LS and femur at 24 months (P < .05). Two years after transplantation >60% of recipients showed stabilization or gain in bone mass. A sufficient calcitriol level in the early transplant period, an adequate iPTH, good renal function, and tacrolimus therapy prevented BMD disease progression.

• Authors: K Falkiewicz, M Boratyńska, S C Zmonarski, A Milewicz, D Patrzałek, P Biecek, M Klinger
• Journal: Transplantation proceedings (Transplant Proc) Vol. 41 Issue 8 Pg. 3063-6 (Oct 2009) ISSN: 1873-2623 [Electronic] United States
• PMID: 19857677 (Publication Type: Journal Article)

Chemical References

• Collagen Type I
• Immunosuppressive Agents
• Parathyroid Hormone
• Peptide Fragments
• Peptides
• Procollagen
• collagen type I trimeric cross-linked peptide
• Osteocalcin
• Creatinine
• Calcitriol

Topics

• Adult
• Bone Density (physiology)
• Bone Diseases (epidemiology, prevention & control)
• Calcitriol (blood)
• Collagen Type I
• Creatinine (blood)
• Female
• Humans
• Immunosuppressive Agents (therapeutic use)
• Kidney Transplantation (adverse effects, immunology)
• Male
• Middle Aged
• Osteocalcin (blood)
• Parathyroid Hormone (blood)
• Peptide Fragments (blood)
• Peptides
• Postoperative Complications (epidemiology)
• Procollagen (blood)