Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A--medical results.

Abstract

BACKGROUND:

This study investigated the effect of oral dimercapto succinic acid (DMSA) therapy for children with autism spectrum disorders ages 3-8 years.

METHODS:

Phase 1 involved 65 children who received one round of DMSA (3 days). Participants who had high urinary excretion of toxic metals were selected to continue on to phase 2. In phase 2, 49 participants were randomly assigned in a double-blind design to receive an additional 6 rounds of either DMSA or placebo.

RESULTS:

DMSA greatly increased the excretion of lead, substantially increased excretion of tin and bismuth, and somewhat increased the excretion of thallium, mercury, antimony, and tungsten. There was some increase in urinary excretion of essential minerals, especially potassium and chromium. The Phase 1 single round of DMSA led to a dramatic normalization of RBC glutathione in almost all cases, and greatly improved abnormal platelet counts, suggesting a significant decrease in inflammation.

CONCLUSION:

Overall, DMSA therapy seems to be reasonably safe, effective in removing several toxic metals (especially lead), dramatically effective in normalizing RBC glutathione, and effective in normalizing platelet counts. Only 1 round (3 days) was sufficient to improve glutathione and platelets. Additional rounds increased excretion of toxic metals.

• Authors: James B Adams, Matthew Baral, Elizabeth Geis, Jessica Mitchell, Julie Ingram, Andrea Hensley, Irene Zappia, Sanford Newmark, Eva Gehn, Robert A Rubin, Ken Mitchell, Jeff Bradstreet, Jane El-Dahr
• Journal: BMC clinical pharmacology (BMC Clin Pharmacol) Vol. 9 Pg. 16 (Oct 23 2009) ISSN: 1472-6904 [Electronic] England
• PMID: 19852789 (Publication Type: Clinical Trial, Phase I, Clinical Trial, Phase II, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Metals
• Succimer
• Glutathione

Topics

• Administration, Oral
• Autistic Disorder (blood, drug therapy, urine)
• Blood Cell Count (methods)
• Child
• Child, Preschool
• Double-Blind Method
• Female
• Glutathione (blood, urine)
• Humans
• Male
• Metals (blood, urine)
• Succimer (administration & dosage, adverse effects)
• Treatment Outcome