Nonsteroidal selective androgen receptor modulator Ostarine in cancer cachexia.

Abstract

Cancer cachexia is a complex syndrome, affecting up to 60% of the approximately 1.4 million patients diagnosed with cancer each year in the USA. This condition is characterized by progressive deterioration of a patient's nutritional status, weight loss, anorexia, diminished quality of life and increased mortality and morbidity. Current therapy with progestational, anti-inflammatory and anabolic agents is often ineffective and has a large number of undesirable effects. The newly developed nonsteroidal selective androgen receptor modulator Ostarine has demonstrated promising results in Phase I and II clinical trials, increasing total lean body mass, enhancing functional performance and decreasing total tissue percent fat. This selective androgen receptor modulator may have the ability to perform as a potent anabolic agent with minimal side effects on other organs (prostate and hair follicles), thus presenting a new strategy in managing cancer cachexia. However, more extensive data is required before its efficacy is confirmed.

• Authors: Mihail F Zilbermint, Adrian S Dobs
• Journal: Future oncology (London, England) (Future Oncol) Vol. 5 Issue 8 Pg. 1211-20 (Oct 2009) ISSN: 1744-8301 [Electronic] England
• PMID: 19852734 (Publication Type: Journal Article, Review)

Chemical References

• Amides
• Anilides
• Receptors, Androgen
• ostarine
• propionamide

Topics

• Amides (pharmacology)
• Anilides
• Cachexia (drug therapy, etiology)
• Clinical Trials as Topic
• Humans
• Neoplasms (complications)
• Receptors, Androgen (drug effects)