Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.

Abstract

There is evidence that the obesity phenotype in the Caucasian populations is associated with variations in several genes, including neuronal growth regulator 1 (NEGR1), SEC16 homolog B (SCE16B), transmembrane protein 18 (TMEM18), ets variant 5 (ETV5), glucosamine-6-phosphate deaminase 2 (GNPDA2), prolactin (PRL), brain-derived neurotrophic factor (BDNF), mitochondrial carrier homolog 2 (MTCH2), Fas apoptotic inhibitory molecule 2 (FAIM2), SH2B adaptor protein 1 (SH2B1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog (MAF), Niemann-Pick disease, type C1 (NPC1), melanocortin 4 receptor (MC4R) and potassium channel tetramerisation domain containing 15 (KCTD15). To investigate the relationship between obesity and these genes in the Japanese population, we genotyped 27 single-nucleotide polymorphisms (SNPs) in 14 genes from obese subjects (n=1129, body mass index (BMI) > or =30 kg m(-2)) and normal-weight control subjects (n=1736, BMI <25 kg m(-2)). The SNP rs10913469 in SEC16B (P=0.000012) and four SNPs (rs2867125, rs6548238, rs4854344 and rs7561317) in the TMEM18 gene (P=0.00015), all of which were in almost absolute linkage disequilibrium, were significantly associated with obesity in the Japanese population. SNPs in GNPDA2, BDNF, FAIM2 and MC4R genes were marginally associated with obesity (P<0.05). Our data suggest that some SNPs identified by genome-wide association studies in the Caucasians also confer susceptibility to obesity in Japanese subjects.

• Authors: Kikuko Hotta, Michihiro Nakamura, Takahiro Nakamura, Tomoaki Matsuo, Yoshio Nakata, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ryoya Komatsu, Naoto Itoh, Ikuo Mineo, Jun Wada, Hiroaki Masuzaki, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Manabu Kawamoto, Takato Ueno, Kazuyuki Hamaguchi, Kiyoji Tanaka, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Hironobu Yoshimatsu, Kazuwa Nakao, Toshiie Sakata, Yuji Matsuzawa, Naoyuki Kamatani, Yusuke Nakamura
• Journal: Journal of human genetics (J Hum Genet) Vol. 54 Issue 12 Pg. 727-31 (Dec 2009) ISSN: 1435-232X [Electronic] England
• PMID: 19851340 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apoptosis Regulatory Proteins
• Brain-Derived Neurotrophic Factor
• DNA-Binding Proteins
• FAIM2 protein, human
• MC4R protein, human
• Membrane Proteins
• Receptor, Melanocortin, Type 4
• SEC16B protein, human
• TMEM18 protein, human
• glucosamine-6-phosphate isomerase
• Aldose-Ketose Isomerases

Topics

• Adult
• Aldose-Ketose Isomerases (genetics)
• Apoptosis Regulatory Proteins (genetics)
• Asian People (genetics)
• Body Mass Index
• Brain-Derived Neurotrophic Factor (genetics)
• Chi-Square Distribution
• DNA-Binding Proteins (genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Japan
• Linkage Disequilibrium
• Male
• Membrane Proteins (genetics)
• Middle Aged
• Obesity (ethnology, genetics)
• Polymorphism, Single Nucleotide
• Receptor, Melanocortin, Type 4 (genetics)