Abstract | OBJECTIVE: DESIGN: SETTING: Kidneys were procured in seven Dutch procurement areas. PATIENTS: Recipients of kidneys from donors after cardiac death aged 2 to 17 yrs. MEASUREMENTS AND MAIN RESULTS: Prospectively collected data from the Dutch Organ Transplant Registry were analyzed. Donor, graft, and recipient characteristics of all pediatric donations after cardiac death kidney transplantations were documented. Recipients were followed-up for glomerular filtration rate, graft, and patient survival. Eighty-eight patients were transplanted with 90 pediatric donation-after- cardiac-death kidneys, which was 31% of the total number of transplanted pediatric donor kidneys. In 77% of recipients, organs were procured from controlled donors, after withdrawal of supportive treatment. Of all donors, 9% were younger than age 6 yrs. Two patients received their graft preemptively. In the others, the incidence of immediate function, delayed graft function, and primary nonfunction were 49%, 44%, and 7%, respectively. Warm ischemia time > or =25 mins was associated with primary nonfunction. Overall graft and patient survival 5 yrs after transplantation were 80% and 88%, respectively. Graft survival after immediate function and delayed graft function was not different. CONCLUSIONS: Kidneys from pediatric donation after cardiac death are suitable for transplantation and may substantially expand the donor pool with good transplant outcome.
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Authors | Eva E de Vries, Maarten G Snoeijs, Ernest van Heurn |
Journal | Critical care medicine
(Crit Care Med)
Vol. 38
Issue 1
Pg. 249-53
(Jan 2010)
ISSN: 1530-0293 [Electronic] United States |
PMID | 19851095
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adolescent
- Age Factors
- Child
- Child, Preschool
- Cohort Studies
- Death
- Delayed Graft Function
- Female
- Graft Rejection
- Graft Survival
- Humans
- Kaplan-Meier Estimate
- Kidney Transplantation
(ethics, methods, mortality)
- Male
- Netherlands
- Probability
- Prognosis
- Retrospective Studies
- Risk Assessment
- Sex Factors
- Statistics, Nonparametric
- Survival Analysis
- Tissue Donors
- Tissue and Organ Harvesting
- Tissue and Organ Procurement
(ethics, trends)
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