[Effect of buxu huayu qutan decoction on anti-oxidative capacity in aged patients with stable angina pectoris of coronary heart disease].

Abstract

OBJECTIVE:

To investigate the acting mechanism of Buxu Huayu Qutan Decoction (BHQD) for impacting the anti-oxidative capacity in aged patients with stable angina pectoris of coronary heart disease (AP-CHD).

METHODS:

Forty patients of AP-CHD, Chinese medicine diagnosed as Xiong-bi, were equally assigned to the treatment group and the control group. Superoxide dismutase (SOD) activity and lipid peroxide (LPO) contents in blood, and mRNA expression of manganese-containing superoxide dismutase (MnSOD) in peripheral mononuclear cells were determined before and after treatment by biochemical and molecular biologic techniques.

RESULTS:

No significant change of plasma SOD and LPO was found in the control group after treatment (P >0.05), while the plasma SOD activity increased and LPO content lowered in the treatment group significantly (P<0.01). Moreover, mRNA expression of MnSOD in the treatment group after treatment was obviously higher than that in the control group (P <0.01).

CONCLUSIONS:

The acting mechanism of BHQD for AP-CHD treatment might partially due to its effects in inducing gene expression of MnSOD in mononuclear cells, enhancing SOD activity, decreasing LPO content, maintaining oxidation/antioxidation equilibrium in myocardial cells, blocking the chain reaction of lipid peroxidation, intervening the production and enhancing the scavenging of oxygen free radicals.

• Authors: Ling-Yun Yan, Yu-Quan Zhang, Xi-Mei Wang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 29 Issue 8 Pg. 695-7 (Aug 2009) ISSN: 1003-5370 [Print] China
• PMID: 19848199 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Drugs, Chinese Herbal
• Lipid Peroxides
• Superoxide Dismutase

Topics

• Aged
• Angina Pectoris (drug therapy, metabolism)
• Coronary Disease (drug therapy, metabolism)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Female
• Humans
• Lipid Peroxidation
• Lipid Peroxides (blood)
• Male
• Middle Aged
• Oxidative Stress
• Phytotherapy
• Superoxide Dismutase (metabolism)