The purpose of this study was to compare the ability of multidetector computed tomography (MDCT) and magnetic resonance imaging (MRI) to evaluate treatment results after transarterial chemoembolization (TACE), with a special focus on the influence of
Lipiodol on calculation of
tumor necrosis according to EASL criteria. A total of 115 nodules in 20 patients (17 males, 3 females; 69.5 +/- 9.35 years) with biopsy-proven
hepatocellular carcinoma were treated with TACE. Embolization was performed using a
doxorubicin-
Lipiodol emulsion (group I) or DC Beads loaded with
doxorubicin (group II). Follow-up included triphasic contrast-enhanced 64-row MDCT (collimation, 0.625 mm; slice, 3 mm; contrast bolus, 120 ml
iomeprol; delay by bolus trigger) and contrast-enhanced MRI (T1 native, T2 native; five dynamic contrast-enhanced phases; 0.1 mmol/kg
body weight gadolinium-DTPA; slice thickness, 4 mm).
Residual tumor and the extent of
tumor necrosis were evaluated according to EASL. Contrast enhancement within
tumor lesions was suspected to represent vital
tumor. In the
Lipiodol-based TACE protocol, MDCT underestimated residual viable
tumor compared to MRI, due to
Lipiodol artifacts (23.2% vs 47.7% after first, 11.9% vs 31.2% after second, and 11.4% vs 23.7% after third TACE; p = 0.0014, p < 0.001, and p < 0.001, respectively). In contrast to MDCT, MRI was completely free of any artifacts caused by
Lipiodol. In the DC Bead-based
Lipiodol-free TACE protocol, MRI and CT showed similar
residual tumor and rating of treatment results (46.4% vs 41.2%, 31.9 vs 26.8%, and 26.0% vs 25.6%; n.s.). In conclusion, MRI is superior to MDCT for detection of viable
tumor residuals after
Lipiodol-based TACE. Since viable
tumor tissue is superimposed by
Lipiodol artifacts in MDCT, MRI is mandatory for reliable decision-making during follow-up after
Lipiodol-based TACE protocols.