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Development of antisynthetase syndrome in a patient with rheumatoid arthritis.

Abstract
Rheumatoid arthritis (RA) and antisynthetase syndrome (ASS) are distinct clinical syndromes, and their co-occurrence is rarely encountered. The authors report the case of a 56-year-old female patient with RA of 3 years duration who suddenly developed ASS, and include a review of the literature. The patient was diagnosed with ASS based on; positivity for anti-histidyl-tRNA synthetase (Jo-1) antibody, interstitial lung disease, polyarthritis, and mechanic's hands. High-dose corticosteroid and pulse intravenous cyclophosphamide were used to control the ASS. This case demonstrates that ASS should be considered during clinical presentations due to its potential overlap with RA.
AuthorsCheol-Kyu Park, Tae-Jong Kim, Young-Nan Cho, Il-Soo Kim, Ho-Jun Lee, Kyung-Eun Lee, Seong-Chang Park, Jong-Sun Kim, Dong-Jin Park, Sung-Ji Lee, Seong-Rye Seo, Jeong-Chul Kim, Sang-Gook Song, Shin-Seok Lee, Yong-Wook Park
JournalRheumatology international (Rheumatol Int) Vol. 31 Issue 4 Pg. 529-32 (Apr 2011) ISSN: 1437-160X [Electronic] Germany
PMID19847427 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Topics
  • Arthritis, Rheumatoid (complications)
  • Female
  • Humans
  • Middle Aged
  • Myositis (drug therapy, etiology)

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