Abstract | BACKGROUND: High-intensity focused ultrasound ( HIFU) therapy offers great promise for the treatment of cancer. The histological changes, including the antitumor immunological response, after HIFU treatment was examined in soft tissue sarcoma. MATERIALS AND METHODS: RESULTS: The tumor size in the HIFU group was significantly smaller than the control and survival rate was significantly higher. The numbers of TUNEL-, TRAP-, CD4- and CD8-positive cells infiltrating the tumor were significantly higher in the HIFU group. CONCLUSION: HIFU, even when administered as a single shot, induces apoptosis of tumor cells and intratumoral infiltration of macrophages and lymphocytes.
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Authors | Shuichi Chida, Kyoji Okada, Norio Suzuki, Chiyo Komori, Yoichi Shimada |
Journal | Anticancer research
(Anticancer Res)
Vol. 29
Issue 10
Pg. 3877-82
(Oct 2009)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 19846922
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- High-Intensity Focused Ultrasound Ablation
(methods)
- Lymphocytes, Tumor-Infiltrating
(immunology)
- Macrophages
(immunology)
- Male
- Mice
- Mice, Inbred ICR
- Sarcoma 180
(immunology, pathology, therapy)
- Skin Neoplasms
(immunology, pathology, therapy)
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