Abstract | PURPOSE: This paper reports on the microbiological findings pertaining to three Serratia isolates from soft contact lens-related corneal ulcers, which represent a complication of contact lens wear reported with increasing frequency. METHODS: RESULTS: Two Serratia marcescens and one Serratia liquefaciens were identified. All the strains were susceptible to aminoglycosides and fluoroquinolones. No isolate formed biofilm or significantly invaded HCE cells; all produced alkaline protease and gelatinase, but not elastase. Opti-Free Express(®) and Opti-Free Replenish(®) were active against S. liquefaciens, but failed to kill the S. marcescens isolates within the minimum recommended time (6 hours). ReNu MultiPlus(®) needed 6 hours to kill one strain of S. marcescens, which is 2 hours more than recommended. Conversely, Oxysept Comfort(®) was always effective within the minimum recommended time (6 hours). CONCLUSIONS:
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Authors | Antonio Pinna, Donatella Usai, Leonardo A Sechi, Arturo Carta, Stefania Zanetti |
Journal | Acta ophthalmologica
(Acta Ophthalmol)
Vol. 89
Issue 4
Pg. 382-7
(Jun 2011)
ISSN: 1755-3768 [Electronic] England |
PMID | 19845561
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2009 The Authors. Journal compilation © 2009 Acta Ophthalmol. |
Chemical References |
- Anti-Bacterial Agents
- Contact Lens Solutions
- Virulence Factors
- Serine Endopeptidases
- Pancreatic Elastase
- microbial serine proteinases
- Gelatinases
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Topics |
- Adult
- Anti-Bacterial Agents
(pharmacology)
- Biofilms
- Cells, Cultured
- Contact Lens Solutions
(pharmacology)
- Contact Lenses, Hydrophilic
(microbiology)
- Corneal Ulcer
(microbiology)
- Epithelium, Corneal
(microbiology)
- Eye Infections, Bacterial
(microbiology)
- Female
- Gelatinases
(metabolism)
- Humans
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Myopia
(therapy)
- Pancreatic Elastase
(metabolism)
- Serine Endopeptidases
(metabolism)
- Serratia Infections
(microbiology)
- Serratia liquefaciens
(drug effects, isolation & purification, physiology)
- Serratia marcescens
(drug effects, isolation & purification, physiology)
- Virulence Factors
(metabolism)
- Young Adult
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