Cytotoxic and anticarcinogenic activity of the ent-kaurene diterpenoid, melissoidesin, from Isodon wightii (Bentham) H. Hara.

Abstract

Isodon wightii is a common plant found in the Western Ghats of South India. The ent-kaurene diterpenoid melissoidesin, isolated from the leaves of I. wightii, showed significant cytotoxicity against lung cancer and neuroblastoma cell lines with IC(50) values of 6 and 4.2 microg mL(-1), respectively. The prevention of deoxyribose degradation activity of melissoidesin was significant and the IC(50) value was calculated to be 163.1 microg mL(-1). The anticarcinogenic activity of melissoidesin by comet assay showed significant DNA damage protecting activity in a dose-dependent manner.

• Authors: R Thirugnanasampandan, R Jayakumar
• Journal: Natural product research (Nat Prod Res) Vol. 23 Issue 16 Pg. 1499-506 ( 2009) ISSN: 1478-6427 [Electronic] England
• PMID: 19844824 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes, Kaurane
• Plant Extracts
• melissoidesin
• Deoxyribose

Topics

• Antineoplastic Agents, Phytogenic (chemistry, pharmacology, therapeutic use, toxicity)
• Cell Line, Tumor
• Cells, Cultured
• Comet Assay
• Deoxyribose (metabolism)
• Diterpenes, Kaurane (chemistry, pharmacology, therapeutic use, toxicity)
• Humans
• India
• Isodon (chemistry)
• Lung Neoplasms (drug therapy)
• Lymphocytes (drug effects)
• Molecular Structure
• Neuroblastoma (drug therapy)
• Plant Extracts (chemistry, pharmacology, toxicity)
• Plant Leaves (chemistry)