Abstract |
Isodon wightii is a common plant found in the Western Ghats of South India. The ent-kaurene diterpenoid melissoidesin, isolated from the leaves of I. wightii, showed significant cytotoxicity against lung cancer and neuroblastoma cell lines with IC(50) values of 6 and 4.2 microg mL(-1), respectively. The prevention of deoxyribose degradation activity of melissoidesin was significant and the IC(50) value was calculated to be 163.1 microg mL(-1). The anticarcinogenic activity of melissoidesin by comet assay showed significant DNA damage protecting activity in a dose-dependent manner.
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Authors | R Thirugnanasampandan, R Jayakumar |
Journal | Natural product research
(Nat Prod Res)
Vol. 23
Issue 16
Pg. 1499-506
( 2009)
ISSN: 1478-6427 [Electronic] England |
PMID | 19844824
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Diterpenes, Kaurane
- Plant Extracts
- melissoidesin
- Deoxyribose
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Topics |
- Antineoplastic Agents, Phytogenic
(chemistry, pharmacology, therapeutic use, toxicity)
- Cell Line, Tumor
- Cells, Cultured
- Comet Assay
- Deoxyribose
(metabolism)
- Diterpenes, Kaurane
(chemistry, pharmacology, therapeutic use, toxicity)
- Humans
- India
- Isodon
(chemistry)
- Lung Neoplasms
(drug therapy)
- Lymphocytes
(drug effects)
- Molecular Structure
- Neuroblastoma
(drug therapy)
- Plant Extracts
(chemistry, pharmacology, toxicity)
- Plant Leaves
(chemistry)
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