Abstract | BACKGROUND AND OBJECTIVES: The antiobesity effects of suppressed endocannabinoid signaling may rely, at least in part, on changes in lipid fluxes. As fatty acids exert specific effects depending on their level of saturation, we hypothesized that the dietary fatty acid composition would influence the outcome of treatment with a CB(1)-receptor antagonist ( rimonabant). METHODS: RESULTS: Relative to the LF diet, the HF diet caused anticipated metabolic derangements, which were partly reversed by the HF/FO diet. The HF/FO diet, however, was most obesity-promoting despite inhibiting lipogenesis as indicated by low gene expression levels of lipogenic enzymes. On all three diets, rimonabant treatment improved metabolic derangements and led to significantly lower body weight gain than their respective controls. This latter effect appeared largest in the HF/FO group, but occurred without major changes in nutrient absorption and energy expenditure. CONCLUSION: The effects of chronic rimonabant treatment on body weight gain occurred irrespective of diet-induced changes in lipogenic activity, food intake and daily energy expenditure, and were, in fact, most pronounced in HF/FO mice. The effects of dietary PUFA replacement in an HF diet on expansion of adipose tissue might allow the favorable effects of dietary PUFA on dyslipidemia and hepatic steatosis. In light of other disadvantageous effects of weight gain, this might be a risky trade-off.
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Authors | A H Koolman, V W Bloks, M H Oosterveer, I Jonas, F Kuipers, P J J Sauer, G van Dijk |
Journal | International journal of obesity (2005)
(Int J Obes (Lond))
Vol. 34
Issue 2
Pg. 374-84
(Feb 2010)
ISSN: 1476-5497 [Electronic] England |
PMID | 19844210
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cannabinoids
- Dietary Fats
- Fatty Acids
- Fish Oils
- Piperidines
- Pyrazoles
- Receptor, Cannabinoid, CB1
- Rimonabant
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Topics |
- Animals
- Body Weight
(drug effects)
- Cannabinoids
(antagonists & inhibitors)
- Dietary Fats
(metabolism, pharmacology)
- Energy Metabolism
(drug effects)
- Fatty Acids
(metabolism)
- Fish Oils
(administration & dosage, metabolism)
- Gene Expression Regulation, Enzymologic
- Male
- Mice
- Mice, Inbred C57BL
- Obesity
(drug therapy, genetics, metabolism)
- Piperidines
(administration & dosage)
- Pyrazoles
(administration & dosage)
- Receptor, Cannabinoid, CB1
(antagonists & inhibitors)
- Rimonabant
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